Tissue macrophages: heterogeneity and functions

Macrophages are present in all vertebrate tissues, from mid-gestation throughout life, constituting a widely dispersed organ system. They promote homeostasis by responding to internal and external changes within the body, not only as phagocytes in defence against microbes and in clearance of dead an...

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Detalles Bibliográficos
Autores principales: Gordon, Siamon, Plüddemann, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492929/
https://www.ncbi.nlm.nih.gov/pubmed/28662662
http://dx.doi.org/10.1186/s12915-017-0392-4
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author Gordon, Siamon
Plüddemann, Annette
author_facet Gordon, Siamon
Plüddemann, Annette
author_sort Gordon, Siamon
collection PubMed
description Macrophages are present in all vertebrate tissues, from mid-gestation throughout life, constituting a widely dispersed organ system. They promote homeostasis by responding to internal and external changes within the body, not only as phagocytes in defence against microbes and in clearance of dead and senescent cells, but also through trophic, regulatory and repair functions. In this review, we describe macrophage phenotypic heterogeneity in different tissue environments, drawing particular attention to organ-specific functions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12915-017-0392-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-54929292017-06-30 Tissue macrophages: heterogeneity and functions Gordon, Siamon Plüddemann, Annette BMC Biol Review Macrophages are present in all vertebrate tissues, from mid-gestation throughout life, constituting a widely dispersed organ system. They promote homeostasis by responding to internal and external changes within the body, not only as phagocytes in defence against microbes and in clearance of dead and senescent cells, but also through trophic, regulatory and repair functions. In this review, we describe macrophage phenotypic heterogeneity in different tissue environments, drawing particular attention to organ-specific functions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12915-017-0392-4) contains supplementary material, which is available to authorized users. BioMed Central 2017-06-29 /pmc/articles/PMC5492929/ /pubmed/28662662 http://dx.doi.org/10.1186/s12915-017-0392-4 Text en © Gordon et al. 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Gordon, Siamon
Plüddemann, Annette
Tissue macrophages: heterogeneity and functions
title Tissue macrophages: heterogeneity and functions
title_full Tissue macrophages: heterogeneity and functions
title_fullStr Tissue macrophages: heterogeneity and functions
title_full_unstemmed Tissue macrophages: heterogeneity and functions
title_short Tissue macrophages: heterogeneity and functions
title_sort tissue macrophages: heterogeneity and functions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492929/
https://www.ncbi.nlm.nih.gov/pubmed/28662662
http://dx.doi.org/10.1186/s12915-017-0392-4
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