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Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis

BACKGROUND: The importance of the mTOR complex 2 (mTORC2) signaling complex in tumor progression is becoming increasingly recognized. HER2-amplified breast cancers use Rictor/mTORC2 signaling to drive tumor formation, tumor cell survival and resistance to human epidermal growth factor receptor 2 (HE...

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Detalles Bibliográficos
Autores principales:	Morrison Joly, Meghan, Williams, Michelle M., Hicks, Donna J., Jones, Bayley, Sanchez, Violeta, Young, Christian D., Sarbassov, Dos D., Muller, William J., Brantley-Sieders, Dana, Cook, Rebecca S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493112/ https://www.ncbi.nlm.nih.gov/pubmed/28666462 http://dx.doi.org/10.1186/s13058-017-0868-8

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