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A Case of Imatinib-Induced Hepatitis
A 71-year-old female with a past medical history of Philadelphia chromosome-positive chronic myelogenous leukemia on imatinib therapy, Sjogren’s syndrome, and hypothyroidism presents with acute hepatitis. After a comprehensive workup ruling out viral, infectious and metabolic etiologies imatinib is...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493456/ https://www.ncbi.nlm.nih.gov/pubmed/28690936 http://dx.doi.org/10.7759/cureus.1302 |
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author | Bhatty, Osman Selim, Mohammad Kassim, Thamer Chintalacheruvu, Lakshmi Urra, Manuel Shah, Sonia Haggerty, Joseph Gross, John Jhand, Aravdeep Pershwitz, Gene Gupta, Jaya |
author_facet | Bhatty, Osman Selim, Mohammad Kassim, Thamer Chintalacheruvu, Lakshmi Urra, Manuel Shah, Sonia Haggerty, Joseph Gross, John Jhand, Aravdeep Pershwitz, Gene Gupta, Jaya |
author_sort | Bhatty, Osman |
collection | PubMed |
description | A 71-year-old female with a past medical history of Philadelphia chromosome-positive chronic myelogenous leukemia on imatinib therapy, Sjogren’s syndrome, and hypothyroidism presents with acute hepatitis. After a comprehensive workup ruling out viral, infectious and metabolic etiologies imatinib is stopped which results in immediate improvement. The biopsy is consistent with drug-induced liver damage; the patient is started on oral prednisone and discharged. Unfortunately, our patient’s liver function does not improve over the course of the next week and she is readmitted for hepatic and renal failure. During this second admission patient’s condition continues to deteriorate with concomitant gastric bleeding, renal injury, and cellulitis. She ultimately chooses a palliative approach. |
format | Online Article Text |
id | pubmed-5493456 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-54934562017-07-07 A Case of Imatinib-Induced Hepatitis Bhatty, Osman Selim, Mohammad Kassim, Thamer Chintalacheruvu, Lakshmi Urra, Manuel Shah, Sonia Haggerty, Joseph Gross, John Jhand, Aravdeep Pershwitz, Gene Gupta, Jaya Cureus Oncology A 71-year-old female with a past medical history of Philadelphia chromosome-positive chronic myelogenous leukemia on imatinib therapy, Sjogren’s syndrome, and hypothyroidism presents with acute hepatitis. After a comprehensive workup ruling out viral, infectious and metabolic etiologies imatinib is stopped which results in immediate improvement. The biopsy is consistent with drug-induced liver damage; the patient is started on oral prednisone and discharged. Unfortunately, our patient’s liver function does not improve over the course of the next week and she is readmitted for hepatic and renal failure. During this second admission patient’s condition continues to deteriorate with concomitant gastric bleeding, renal injury, and cellulitis. She ultimately chooses a palliative approach. Cureus 2017-06-01 /pmc/articles/PMC5493456/ /pubmed/28690936 http://dx.doi.org/10.7759/cureus.1302 Text en Copyright © 2017, Bhatty et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Oncology Bhatty, Osman Selim, Mohammad Kassim, Thamer Chintalacheruvu, Lakshmi Urra, Manuel Shah, Sonia Haggerty, Joseph Gross, John Jhand, Aravdeep Pershwitz, Gene Gupta, Jaya A Case of Imatinib-Induced Hepatitis |
title | A Case of Imatinib-Induced Hepatitis |
title_full | A Case of Imatinib-Induced Hepatitis |
title_fullStr | A Case of Imatinib-Induced Hepatitis |
title_full_unstemmed | A Case of Imatinib-Induced Hepatitis |
title_short | A Case of Imatinib-Induced Hepatitis |
title_sort | case of imatinib-induced hepatitis |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493456/ https://www.ncbi.nlm.nih.gov/pubmed/28690936 http://dx.doi.org/10.7759/cureus.1302 |
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