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A Case of Imatinib-Induced Hepatitis

A 71-year-old female with a past medical history of Philadelphia chromosome-positive chronic myelogenous leukemia on imatinib therapy, Sjogren’s syndrome, and hypothyroidism presents with acute hepatitis. After a comprehensive workup ruling out viral, infectious and metabolic etiologies imatinib is...

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Autores principales: Bhatty, Osman, Selim, Mohammad, Kassim, Thamer, Chintalacheruvu, Lakshmi, Urra, Manuel, Shah, Sonia, Haggerty, Joseph, Gross, John, Jhand, Aravdeep, Pershwitz, Gene, Gupta, Jaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493456/
https://www.ncbi.nlm.nih.gov/pubmed/28690936
http://dx.doi.org/10.7759/cureus.1302
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author Bhatty, Osman
Selim, Mohammad
Kassim, Thamer
Chintalacheruvu, Lakshmi
Urra, Manuel
Shah, Sonia
Haggerty, Joseph
Gross, John
Jhand, Aravdeep
Pershwitz, Gene
Gupta, Jaya
author_facet Bhatty, Osman
Selim, Mohammad
Kassim, Thamer
Chintalacheruvu, Lakshmi
Urra, Manuel
Shah, Sonia
Haggerty, Joseph
Gross, John
Jhand, Aravdeep
Pershwitz, Gene
Gupta, Jaya
author_sort Bhatty, Osman
collection PubMed
description A 71-year-old female with a past medical history of Philadelphia chromosome-positive chronic myelogenous leukemia on imatinib therapy, Sjogren’s syndrome, and hypothyroidism presents with acute hepatitis. After a comprehensive workup ruling out viral, infectious and metabolic etiologies imatinib is stopped which results in immediate improvement. The biopsy is consistent with drug-induced liver damage; the patient is started on oral prednisone and discharged. Unfortunately, our patient’s liver function does not improve over the course of the next week and she is readmitted for hepatic and renal failure. During this second admission patient’s condition continues to deteriorate with concomitant gastric bleeding, renal injury, and cellulitis. She ultimately chooses a palliative approach.
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spelling pubmed-54934562017-07-07 A Case of Imatinib-Induced Hepatitis Bhatty, Osman Selim, Mohammad Kassim, Thamer Chintalacheruvu, Lakshmi Urra, Manuel Shah, Sonia Haggerty, Joseph Gross, John Jhand, Aravdeep Pershwitz, Gene Gupta, Jaya Cureus Oncology A 71-year-old female with a past medical history of Philadelphia chromosome-positive chronic myelogenous leukemia on imatinib therapy, Sjogren’s syndrome, and hypothyroidism presents with acute hepatitis. After a comprehensive workup ruling out viral, infectious and metabolic etiologies imatinib is stopped which results in immediate improvement. The biopsy is consistent with drug-induced liver damage; the patient is started on oral prednisone and discharged. Unfortunately, our patient’s liver function does not improve over the course of the next week and she is readmitted for hepatic and renal failure. During this second admission patient’s condition continues to deteriorate with concomitant gastric bleeding, renal injury, and cellulitis. She ultimately chooses a palliative approach. Cureus 2017-06-01 /pmc/articles/PMC5493456/ /pubmed/28690936 http://dx.doi.org/10.7759/cureus.1302 Text en Copyright © 2017, Bhatty et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Oncology
Bhatty, Osman
Selim, Mohammad
Kassim, Thamer
Chintalacheruvu, Lakshmi
Urra, Manuel
Shah, Sonia
Haggerty, Joseph
Gross, John
Jhand, Aravdeep
Pershwitz, Gene
Gupta, Jaya
A Case of Imatinib-Induced Hepatitis
title A Case of Imatinib-Induced Hepatitis
title_full A Case of Imatinib-Induced Hepatitis
title_fullStr A Case of Imatinib-Induced Hepatitis
title_full_unstemmed A Case of Imatinib-Induced Hepatitis
title_short A Case of Imatinib-Induced Hepatitis
title_sort case of imatinib-induced hepatitis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493456/
https://www.ncbi.nlm.nih.gov/pubmed/28690936
http://dx.doi.org/10.7759/cureus.1302
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