Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells

Aberrant cytokine signaling initiated from mutant receptor tyrosine kinases (RTKs) provides critical growth and survival signals in high risk acute myeloid leukemia (AML). Inhibitors to FLT3 have already been tested in clinical trials, however, drug resistance limits clinical efficacy. Mutant recept...

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Detalles Bibliográficos
Autores principales: Metts, Jonathan, Bradley, Heath L., Wang, Zhengqi, Shah, Neil P., Kapur, Reuben, Arbiser, Jack L., Bunting, Kevin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493614/
https://www.ncbi.nlm.nih.gov/pubmed/28667329
http://dx.doi.org/10.1038/s41598-017-04796-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493614/
https://www.ncbi.nlm.nih.gov/pubmed/28667329
http://dx.doi.org/10.1038/s41598-017-04796-1

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