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Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells
Aberrant cytokine signaling initiated from mutant receptor tyrosine kinases (RTKs) provides critical growth and survival signals in high risk acute myeloid leukemia (AML). Inhibitors to FLT3 have already been tested in clinical trials, however, drug resistance limits clinical efficacy. Mutant recept...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493614/ https://www.ncbi.nlm.nih.gov/pubmed/28667329 http://dx.doi.org/10.1038/s41598-017-04796-1 |