Intermolecular steric inhibition of Ephexin4 is relieved by Elmo1

Ephexin4, a guanine nucleotide-exchange factor for RhoG, promotes engulfment of apoptotic cells and cancer cell migration in a RhoG-dependent manner, which is synergistically augmented by Elmo1, an Ephexin4-interacting protein. However, the underlying molecular mechanism remains elusive. Here, we re...

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Detalles Bibliográficos
Autores principales: Kim, Kwanhyeong, Lee, Juyeon, Lee, Sang-Ah, Moon, Hyunji, Park, Boyeon, Kim, Deokhwan, Joo, Young-Eun, Park, Daeho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493634/
https://www.ncbi.nlm.nih.gov/pubmed/28667327
http://dx.doi.org/10.1038/s41598-017-04810-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493634/
https://www.ncbi.nlm.nih.gov/pubmed/28667327
http://dx.doi.org/10.1038/s41598-017-04810-6

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