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0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop

DNA-damaging agents have been used in cancer chemotherapy for a long history. Unfortunately, chemotherapeutic treatment strategies against hepatocellular carcinoma (HCC) are still ineffective. We screened a novel DNA-damaging compound, designated as 0404, by using time-dependent cellular response pr...

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Detalles Bibliográficos
Autores principales:	Xia, Caixia, Shui, Liyan, Lou, Guohua, Ye, Bingjue, Zhu, Wei, Wang, Jing, Wu, Shanshan, Xu, Xiao, Mao, Long, Xu, Wanhong, Chen, Zhi, Liu, Yanning, Zheng, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493669/ https://www.ncbi.nlm.nih.gov/pubmed/28667294 http://dx.doi.org/10.1038/s41598-017-04487-x

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