Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation

Programmable sequence-specific genome editing agents such as CRISPR-Cas9 have greatly advanced our ability to manipulate the human genome. Although canonical forms of genome-editing agents and programmable transcriptional regulators are constitutively active, precise temporal and spatial control ove...

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Detalles Bibliográficos
Autores principales: Tang, Weixin, Hu, Johnny H., Liu, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493748/
https://www.ncbi.nlm.nih.gov/pubmed/28656978
http://dx.doi.org/10.1038/ncomms15939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493748/
https://www.ncbi.nlm.nih.gov/pubmed/28656978
http://dx.doi.org/10.1038/ncomms15939

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