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Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation
Programmable sequence-specific genome editing agents such as CRISPR-Cas9 have greatly advanced our ability to manipulate the human genome. Although canonical forms of genome-editing agents and programmable transcriptional regulators are constitutively active, precise temporal and spatial control ove...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493748/ https://www.ncbi.nlm.nih.gov/pubmed/28656978 http://dx.doi.org/10.1038/ncomms15939 |