MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism

Excessive activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is involved in many chronic inflammatory diseases, including cardiovascular and Alzheimer’s disease. Here we show that microtubule-affinity regulating kinase 4 (MARK4) binds to NLRP3 and drives it to the microtubul...

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Detalles Bibliográficos
Autores principales: Li, Xuan, Thome, Sarah, Ma, Xiaodan, Amrute-Nayak, Mamta, Finigan, Alison, Kitt, Lauren, Masters, Leanne, James, John R., Shi, Yuguang, Meng, Guoyu, Mallat, Ziad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493753/
https://www.ncbi.nlm.nih.gov/pubmed/28656979
http://dx.doi.org/10.1038/ncomms15986

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