Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein

Germline mutations in the Folliculin (FLCN) tumour suppressor gene result in fibrofolliculomas, lung cysts and renal cancers, but the precise mechanisms of tumour suppression by FLCN remain elusive. Here we identify Rab7A, a small GTPase important for endocytic trafficking, as a novel FLCN interacti...

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Detalles Bibliográficos
Autores principales: Laviolette, Laura A., Mermoud, Julien, Calvo, Isabel A., Olson, Nicholas, Boukhali, Myriam, Steinlein, Ortrud K., Roider, Elisabeth, Sattler, Elke C., Huang, Dachuan, Teh, Bin Tean, Motamedi, Mo, Haas, Wilhelm, Iliopoulos, Othon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493755/
https://www.ncbi.nlm.nih.gov/pubmed/28656962
http://dx.doi.org/10.1038/ncomms15866

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