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Cell signalling pathway regulation by RanBPM: molecular insights and disease implications

RanBPM (Ran-binding protein M, also called RanBP9) is an evolutionarily conserved, ubiquitous protein which localizes to both nucleus and cytoplasm. RanBPM has been implicated in the regulation of a number of signalling pathways to regulate several cellular processes such as apoptosis, cell adhesion...

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Autores principales: Salemi, Louisa M., Maitland, Matthew E. R., McTavish, Christina J., Schild-Poulter, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493780/
https://www.ncbi.nlm.nih.gov/pubmed/28659384
http://dx.doi.org/10.1098/rsob.170081
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author Salemi, Louisa M.
Maitland, Matthew E. R.
McTavish, Christina J.
Schild-Poulter, Caroline
author_facet Salemi, Louisa M.
Maitland, Matthew E. R.
McTavish, Christina J.
Schild-Poulter, Caroline
author_sort Salemi, Louisa M.
collection PubMed
description RanBPM (Ran-binding protein M, also called RanBP9) is an evolutionarily conserved, ubiquitous protein which localizes to both nucleus and cytoplasm. RanBPM has been implicated in the regulation of a number of signalling pathways to regulate several cellular processes such as apoptosis, cell adhesion, migration as well as transcription, and plays a critical role during development. In addition, RanBPM has been shown to regulate pathways implicated in cancer and Alzheimer's disease, implying that RanBPM has important functions in both normal and pathological development. While its functions in these processes are still poorly understood, RanBPM has been identified as a component of a large complex, termed the CTLH (C-terminal to LisH) complex. The yeast homologue of this complex functions as an E3 ubiquitin ligase that targets enzymes of the gluconeogenesis pathway. While the CTLH complex E3 ubiquitin ligase activity and substrates still remain to be characterized, the high level of conservation between the complexes in yeast and mammals infers that the CTLH complex could also serve to promote the degradation of specific substrates through ubiquitination, therefore suggesting the possibility that RanBPM's various functions may be mediated through the activity of the CTLH complex.
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spelling pubmed-54937802017-07-05 Cell signalling pathway regulation by RanBPM: molecular insights and disease implications Salemi, Louisa M. Maitland, Matthew E. R. McTavish, Christina J. Schild-Poulter, Caroline Open Biol Review RanBPM (Ran-binding protein M, also called RanBP9) is an evolutionarily conserved, ubiquitous protein which localizes to both nucleus and cytoplasm. RanBPM has been implicated in the regulation of a number of signalling pathways to regulate several cellular processes such as apoptosis, cell adhesion, migration as well as transcription, and plays a critical role during development. In addition, RanBPM has been shown to regulate pathways implicated in cancer and Alzheimer's disease, implying that RanBPM has important functions in both normal and pathological development. While its functions in these processes are still poorly understood, RanBPM has been identified as a component of a large complex, termed the CTLH (C-terminal to LisH) complex. The yeast homologue of this complex functions as an E3 ubiquitin ligase that targets enzymes of the gluconeogenesis pathway. While the CTLH complex E3 ubiquitin ligase activity and substrates still remain to be characterized, the high level of conservation between the complexes in yeast and mammals infers that the CTLH complex could also serve to promote the degradation of specific substrates through ubiquitination, therefore suggesting the possibility that RanBPM's various functions may be mediated through the activity of the CTLH complex. The Royal Society 2017-06-28 /pmc/articles/PMC5493780/ /pubmed/28659384 http://dx.doi.org/10.1098/rsob.170081 Text en © 2017 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Review
Salemi, Louisa M.
Maitland, Matthew E. R.
McTavish, Christina J.
Schild-Poulter, Caroline
Cell signalling pathway regulation by RanBPM: molecular insights and disease implications
title Cell signalling pathway regulation by RanBPM: molecular insights and disease implications
title_full Cell signalling pathway regulation by RanBPM: molecular insights and disease implications
title_fullStr Cell signalling pathway regulation by RanBPM: molecular insights and disease implications
title_full_unstemmed Cell signalling pathway regulation by RanBPM: molecular insights and disease implications
title_short Cell signalling pathway regulation by RanBPM: molecular insights and disease implications
title_sort cell signalling pathway regulation by ranbpm: molecular insights and disease implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493780/
https://www.ncbi.nlm.nih.gov/pubmed/28659384
http://dx.doi.org/10.1098/rsob.170081
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