HLA-B*1502 in Iranian Children with Anticonvulsant Drugs-Induced Skin Reactions

OBJECTIVE: Anticonvulsant drugs can cause various forms of skin drug reactions, ranging from exanthema to severe blistering reactions. An association between HLA-B*1502 allele and severe skin reactions have been reported. MATERIALS & METHODS: Fifteen patients with severe skin reactions following...

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Autores principales: TONEKABONI, Seyed Hasan, JAFARI, Narjes, MANSOURI, Mahboubeh, JABBEHDARI, Sayena, EFTEKHARI, Rahil, CHAVOSHZADEH, Zahra, ABDOLLAH GORJI, Fatemeh, MESDAGHI, Mehrnaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shahid Beheshti University of Medical Sciences 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493826/
https://www.ncbi.nlm.nih.gov/pubmed/28698724
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author TONEKABONI, Seyed Hasan
JAFARI, Narjes
MANSOURI, Mahboubeh
JABBEHDARI, Sayena
EFTEKHARI, Rahil
CHAVOSHZADEH, Zahra
ABDOLLAH GORJI, Fatemeh
MESDAGHI, Mehrnaz
author_facet TONEKABONI, Seyed Hasan
JAFARI, Narjes
MANSOURI, Mahboubeh
JABBEHDARI, Sayena
EFTEKHARI, Rahil
CHAVOSHZADEH, Zahra
ABDOLLAH GORJI, Fatemeh
MESDAGHI, Mehrnaz
author_sort TONEKABONI, Seyed Hasan
collection PubMed
description OBJECTIVE: Anticonvulsant drugs can cause various forms of skin drug reactions, ranging from exanthema to severe blistering reactions. An association between HLA-B*1502 allele and severe skin reactions have been reported. MATERIALS & METHODS: Fifteen patients with severe skin reactions following treatment with anticonvulsant drugs (Carbamazepine, lamotrigine, phenobarbital, primidone) and 15 controls (age-matched epileptic patients taking similar anticonvulsants without drug eruption) were included. They were referred to Mofid Children’s Hospital in Tehran, Iran, between Jan 2012 to Jan 2014. Genomic DNA was extracted from peripheral blood of all patients and HLA- B*1502 genotype was detected by real-time PCR. RESULTS: None of the patients was positive for HLA- B*1502, but two patients in control group had positive HLA- B*1502. CONCLUSION: The HLA- B*1502 is not correlated with severe anticonvulsant drugs -induced skin reactions in Iranian children.
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spelling pubmed-54938262017-07-11 HLA-B*1502 in Iranian Children with Anticonvulsant Drugs-Induced Skin Reactions TONEKABONI, Seyed Hasan JAFARI, Narjes MANSOURI, Mahboubeh JABBEHDARI, Sayena EFTEKHARI, Rahil CHAVOSHZADEH, Zahra ABDOLLAH GORJI, Fatemeh MESDAGHI, Mehrnaz Iran J Child Neurol Original Article OBJECTIVE: Anticonvulsant drugs can cause various forms of skin drug reactions, ranging from exanthema to severe blistering reactions. An association between HLA-B*1502 allele and severe skin reactions have been reported. MATERIALS & METHODS: Fifteen patients with severe skin reactions following treatment with anticonvulsant drugs (Carbamazepine, lamotrigine, phenobarbital, primidone) and 15 controls (age-matched epileptic patients taking similar anticonvulsants without drug eruption) were included. They were referred to Mofid Children’s Hospital in Tehran, Iran, between Jan 2012 to Jan 2014. Genomic DNA was extracted from peripheral blood of all patients and HLA- B*1502 genotype was detected by real-time PCR. RESULTS: None of the patients was positive for HLA- B*1502, but two patients in control group had positive HLA- B*1502. CONCLUSION: The HLA- B*1502 is not correlated with severe anticonvulsant drugs -induced skin reactions in Iranian children. Shahid Beheshti University of Medical Sciences 2017 /pmc/articles/PMC5493826/ /pubmed/28698724 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
TONEKABONI, Seyed Hasan
JAFARI, Narjes
MANSOURI, Mahboubeh
JABBEHDARI, Sayena
EFTEKHARI, Rahil
CHAVOSHZADEH, Zahra
ABDOLLAH GORJI, Fatemeh
MESDAGHI, Mehrnaz
HLA-B*1502 in Iranian Children with Anticonvulsant Drugs-Induced Skin Reactions
title HLA-B*1502 in Iranian Children with Anticonvulsant Drugs-Induced Skin Reactions
title_full HLA-B*1502 in Iranian Children with Anticonvulsant Drugs-Induced Skin Reactions
title_fullStr HLA-B*1502 in Iranian Children with Anticonvulsant Drugs-Induced Skin Reactions
title_full_unstemmed HLA-B*1502 in Iranian Children with Anticonvulsant Drugs-Induced Skin Reactions
title_short HLA-B*1502 in Iranian Children with Anticonvulsant Drugs-Induced Skin Reactions
title_sort hla-b*1502 in iranian children with anticonvulsant drugs-induced skin reactions
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493826/
https://www.ncbi.nlm.nih.gov/pubmed/28698724
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