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Association of 25-Hydroxyvitamin D Deficiency in Pediatric Epileptic Patients

OBJECTIVE: Epilepsy is a chronic neurological disorder requiring long-term therapy using antiepileptic medications. Reports have incriminated long-term antiepileptic drugs use in deficiency of vitamin D and bone diseases in all age groups. We aimed to investigate the association between serum 25-hyd...

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Autores principales: CHAUDHURI, Jaydip Ray, MRIDULA, Kandadai Rukmini, RATHNAKISHORE, Chakrala, BALARAJU, Banda, BANDARU, VCS Srinivasarao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shahid Beheshti University of Medical Sciences 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493830/
https://www.ncbi.nlm.nih.gov/pubmed/28698728
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author CHAUDHURI, Jaydip Ray
MRIDULA, Kandadai Rukmini
RATHNAKISHORE, Chakrala
BALARAJU, Banda
BANDARU, VCS Srinivasarao
author_facet CHAUDHURI, Jaydip Ray
MRIDULA, Kandadai Rukmini
RATHNAKISHORE, Chakrala
BALARAJU, Banda
BANDARU, VCS Srinivasarao
author_sort CHAUDHURI, Jaydip Ray
collection PubMed
description OBJECTIVE: Epilepsy is a chronic neurological disorder requiring long-term therapy using antiepileptic medications. Reports have incriminated long-term antiepileptic drugs use in deficiency of vitamin D and bone diseases in all age groups. We aimed to investigate the association between serum 25-hydroxyvitamin D levels and pediatric epilepsy in Indian patients. MATERIALS & METHODS: We prospectively recruited 100 pediatric epilepsy patients, on monotherapy for minimum one-year duration, and 50 age and sex matched controls. This study was carried out at Yashoda Hospital, India from 2011-2014. All cases and controls underwent tests for serum 25-hydroxyvitamin D, alkaline phosphatase, serum calcium and phosphorus levels. RESULTS: Patients with 25-hydroxyvitamin D deficiency were significantly higher among cases (45%) than controls (24%). Mean alkaline phosphatase was significantly higher in cases and mean serum calcium was significantly lower (8.3±1.5) in cases. Amongst antiepileptic drugs, carbamazepine and sodium valproate were significantly associated with 25-hydroxyvitamin D deficiency. Risk of vitamin D deficiency was highest with sodium valproate usage (odds:4.0;95%CI 1.4-11.6) followed by carbamazepine use (odds: 2.7; 95%CI 1.0-6.8). After adjustment using multiple logistic regression, antiepileptic drugs showed independent association with 25-hydroxyvitamin D deficiency (odds:2.2;95%CI 0.9-4.5). CONCLUSION: 25-hydroxyvitamin D deficiency was significantly associated with use of carbamazepine and sodium valproate in pediatric epilepsy.
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spelling pubmed-54938302017-07-11 Association of 25-Hydroxyvitamin D Deficiency in Pediatric Epileptic Patients CHAUDHURI, Jaydip Ray MRIDULA, Kandadai Rukmini RATHNAKISHORE, Chakrala BALARAJU, Banda BANDARU, VCS Srinivasarao Iran J Child Neurol Original Article OBJECTIVE: Epilepsy is a chronic neurological disorder requiring long-term therapy using antiepileptic medications. Reports have incriminated long-term antiepileptic drugs use in deficiency of vitamin D and bone diseases in all age groups. We aimed to investigate the association between serum 25-hydroxyvitamin D levels and pediatric epilepsy in Indian patients. MATERIALS & METHODS: We prospectively recruited 100 pediatric epilepsy patients, on monotherapy for minimum one-year duration, and 50 age and sex matched controls. This study was carried out at Yashoda Hospital, India from 2011-2014. All cases and controls underwent tests for serum 25-hydroxyvitamin D, alkaline phosphatase, serum calcium and phosphorus levels. RESULTS: Patients with 25-hydroxyvitamin D deficiency were significantly higher among cases (45%) than controls (24%). Mean alkaline phosphatase was significantly higher in cases and mean serum calcium was significantly lower (8.3±1.5) in cases. Amongst antiepileptic drugs, carbamazepine and sodium valproate were significantly associated with 25-hydroxyvitamin D deficiency. Risk of vitamin D deficiency was highest with sodium valproate usage (odds:4.0;95%CI 1.4-11.6) followed by carbamazepine use (odds: 2.7; 95%CI 1.0-6.8). After adjustment using multiple logistic regression, antiepileptic drugs showed independent association with 25-hydroxyvitamin D deficiency (odds:2.2;95%CI 0.9-4.5). CONCLUSION: 25-hydroxyvitamin D deficiency was significantly associated with use of carbamazepine and sodium valproate in pediatric epilepsy. Shahid Beheshti University of Medical Sciences 2017 /pmc/articles/PMC5493830/ /pubmed/28698728 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
CHAUDHURI, Jaydip Ray
MRIDULA, Kandadai Rukmini
RATHNAKISHORE, Chakrala
BALARAJU, Banda
BANDARU, VCS Srinivasarao
Association of 25-Hydroxyvitamin D Deficiency in Pediatric Epileptic Patients
title Association of 25-Hydroxyvitamin D Deficiency in Pediatric Epileptic Patients
title_full Association of 25-Hydroxyvitamin D Deficiency in Pediatric Epileptic Patients
title_fullStr Association of 25-Hydroxyvitamin D Deficiency in Pediatric Epileptic Patients
title_full_unstemmed Association of 25-Hydroxyvitamin D Deficiency in Pediatric Epileptic Patients
title_short Association of 25-Hydroxyvitamin D Deficiency in Pediatric Epileptic Patients
title_sort association of 25-hydroxyvitamin d deficiency in pediatric epileptic patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493830/
https://www.ncbi.nlm.nih.gov/pubmed/28698728
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