Transforming growth factor activating kinase 1 regulates extracellular matrix degrading enzymes and pain-related molecule expression following tumor necrosis factor-α stimulation of synovial cells: an in vitro study

BACKGROUND: Recent studies have suggested that the tumor necrosis factor-α (TNF-α) pathway is a potential target for the management of osteoarthritis (OA). Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) is essential in several cytokine-mediated cascades, including the TNF-α, interleuki...

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Detalles Bibliográficos
Autores principales: Uchida, Kentaro, Takano, Shotaro, Matsumoto, Toshihide, Nagura, Naoshige, Inoue, Gen, Itakura, Makoto, Miyagi, Masayuki, Aikawa, Jun, Iwase, Dai, Minatani, Atsushi, Fujimaki, Hisako, Takaso, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493881/
https://www.ncbi.nlm.nih.gov/pubmed/28668088
http://dx.doi.org/10.1186/s12891-017-1648-4

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