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Precision oncology using a limited number of cells: optimization of whole genome amplification products for sequencing applications

BACKGROUND: Sequencing analysis of circulating tumor cells (CTCs) enables “liquid biopsy” to guide precision oncology strategies. However, this requires low-template whole genome amplification (WGA) that is prone to errors and biases from uneven amplifications. Currently, quality control (QC) method...

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Detalles Bibliográficos
Autores principales:	Sho, Shonan, Court, Colin M., Winograd, Paul, Lee, Sangjun, Hou, Shuang, Graeber, Thomas G., Tseng, Hsian-Rong, Tomlinson, James S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493892/ https://www.ncbi.nlm.nih.gov/pubmed/28666423 http://dx.doi.org/10.1186/s12885-017-3447-6

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