Is Mycobacterium avium paratuberculosis the Trigger in the Crohn’s Disease Spectrum?

We present and discuss a 30-month investigation of a patient that presented with abdominal pain, postprandial diarrhea, bloating, and night sweats and was treated for Crohn’s disease without significant improvement. The patient underwent an ileocecetomy with removal of an atonic segment with resolut...

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Detalles Bibliográficos
Autores principales: Oken, Harry A., Saleeb, Paul G., Redfield, Robert R., Schimpff, Stephen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493936/
https://www.ncbi.nlm.nih.gov/pubmed/28685154
http://dx.doi.org/10.1093/ofid/ofx104
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author Oken, Harry A.
Saleeb, Paul G.
Redfield, Robert R.
Schimpff, Stephen C.
author_facet Oken, Harry A.
Saleeb, Paul G.
Redfield, Robert R.
Schimpff, Stephen C.
author_sort Oken, Harry A.
collection PubMed
description We present and discuss a 30-month investigation of a patient that presented with abdominal pain, postprandial diarrhea, bloating, and night sweats and was treated for Crohn’s disease without significant improvement. The patient underwent an ileocecetomy with removal of an atonic segment with resolution of functional gastrointestinal symptoms, but profound night sweats continued postoperatively. The patient was presumptively treated for a mixed mycobacterial infection, blood cultures later grew Mycobacterium avium paratuberculosis (MAP), and she improved over time. We discuss MAP and its possible relationship to Crohn’s disease.
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spelling pubmed-54939362017-07-06 Is Mycobacterium avium paratuberculosis the Trigger in the Crohn’s Disease Spectrum? Oken, Harry A. Saleeb, Paul G. Redfield, Robert R. Schimpff, Stephen C. Open Forum Infect Dis Brief Report We present and discuss a 30-month investigation of a patient that presented with abdominal pain, postprandial diarrhea, bloating, and night sweats and was treated for Crohn’s disease without significant improvement. The patient underwent an ileocecetomy with removal of an atonic segment with resolution of functional gastrointestinal symptoms, but profound night sweats continued postoperatively. The patient was presumptively treated for a mixed mycobacterial infection, blood cultures later grew Mycobacterium avium paratuberculosis (MAP), and she improved over time. We discuss MAP and its possible relationship to Crohn’s disease. Oxford University Press 2017-05-18 /pmc/articles/PMC5493936/ /pubmed/28685154 http://dx.doi.org/10.1093/ofid/ofx104 Text en © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Report
Oken, Harry A.
Saleeb, Paul G.
Redfield, Robert R.
Schimpff, Stephen C.
Is Mycobacterium avium paratuberculosis the Trigger in the Crohn’s Disease Spectrum?
title Is Mycobacterium avium paratuberculosis the Trigger in the Crohn’s Disease Spectrum?
title_full Is Mycobacterium avium paratuberculosis the Trigger in the Crohn’s Disease Spectrum?
title_fullStr Is Mycobacterium avium paratuberculosis the Trigger in the Crohn’s Disease Spectrum?
title_full_unstemmed Is Mycobacterium avium paratuberculosis the Trigger in the Crohn’s Disease Spectrum?
title_short Is Mycobacterium avium paratuberculosis the Trigger in the Crohn’s Disease Spectrum?
title_sort is mycobacterium avium paratuberculosis the trigger in the crohn’s disease spectrum?
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493936/
https://www.ncbi.nlm.nih.gov/pubmed/28685154
http://dx.doi.org/10.1093/ofid/ofx104
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