Emergence of Ceftazidime-Avibactam Resistance and Restoration of Carbapenem Susceptibility in Klebsiella pneumoniae Carbapenemase-Producing K pneumoniae: A Case Report and Review of Literature

We used meropenem to successfully treat a patient with bacteremia due to ceftazidime-avibactam-resistant, meropenem- susceptible Klebsiella pneumoniae that carried mutant bla(KPC-3). Meropenem was bactericidal against ceftazidime-avibactam- resistant K pneumoniae isolates in vitro. Nevertheless, the...

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Detalles Bibliográficos
Autores principales: Shields, Ryan K., Nguyen, M. Hong, Press, Ellen G., Chen, Liang, Kreiswirth, Barry N., Clancy, Cornelius J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
ID Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493938/
https://www.ncbi.nlm.nih.gov/pubmed/28685153
http://dx.doi.org/10.1093/ofid/ofx101
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author Shields, Ryan K.
Nguyen, M. Hong
Press, Ellen G.
Chen, Liang
Kreiswirth, Barry N.
Clancy, Cornelius J.
author_facet Shields, Ryan K.
Nguyen, M. Hong
Press, Ellen G.
Chen, Liang
Kreiswirth, Barry N.
Clancy, Cornelius J.
author_sort Shields, Ryan K.
collection PubMed
description We used meropenem to successfully treat a patient with bacteremia due to ceftazidime-avibactam-resistant, meropenem- susceptible Klebsiella pneumoniae that carried mutant bla(KPC-3). Meropenem was bactericidal against ceftazidime-avibactam- resistant K pneumoniae isolates in vitro. Nevertheless, the role of carbapenems in treating such infections remains uncertain, because meropenem resistance is selected readily during passage experiments.
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spelling pubmed-54939382017-07-06 Emergence of Ceftazidime-Avibactam Resistance and Restoration of Carbapenem Susceptibility in Klebsiella pneumoniae Carbapenemase-Producing K pneumoniae: A Case Report and Review of Literature Shields, Ryan K. Nguyen, M. Hong Press, Ellen G. Chen, Liang Kreiswirth, Barry N. Clancy, Cornelius J. Open Forum Infect Dis ID Case We used meropenem to successfully treat a patient with bacteremia due to ceftazidime-avibactam-resistant, meropenem- susceptible Klebsiella pneumoniae that carried mutant bla(KPC-3). Meropenem was bactericidal against ceftazidime-avibactam- resistant K pneumoniae isolates in vitro. Nevertheless, the role of carbapenems in treating such infections remains uncertain, because meropenem resistance is selected readily during passage experiments. Oxford University Press 2017-07-01 /pmc/articles/PMC5493938/ /pubmed/28685153 http://dx.doi.org/10.1093/ofid/ofx101 Text en © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle ID Case
Shields, Ryan K.
Nguyen, M. Hong
Press, Ellen G.
Chen, Liang
Kreiswirth, Barry N.
Clancy, Cornelius J.
Emergence of Ceftazidime-Avibactam Resistance and Restoration of Carbapenem Susceptibility in Klebsiella pneumoniae Carbapenemase-Producing K pneumoniae: A Case Report and Review of Literature
title Emergence of Ceftazidime-Avibactam Resistance and Restoration of Carbapenem Susceptibility in Klebsiella pneumoniae Carbapenemase-Producing K pneumoniae: A Case Report and Review of Literature
title_full Emergence of Ceftazidime-Avibactam Resistance and Restoration of Carbapenem Susceptibility in Klebsiella pneumoniae Carbapenemase-Producing K pneumoniae: A Case Report and Review of Literature
title_fullStr Emergence of Ceftazidime-Avibactam Resistance and Restoration of Carbapenem Susceptibility in Klebsiella pneumoniae Carbapenemase-Producing K pneumoniae: A Case Report and Review of Literature
title_full_unstemmed Emergence of Ceftazidime-Avibactam Resistance and Restoration of Carbapenem Susceptibility in Klebsiella pneumoniae Carbapenemase-Producing K pneumoniae: A Case Report and Review of Literature
title_short Emergence of Ceftazidime-Avibactam Resistance and Restoration of Carbapenem Susceptibility in Klebsiella pneumoniae Carbapenemase-Producing K pneumoniae: A Case Report and Review of Literature
title_sort emergence of ceftazidime-avibactam resistance and restoration of carbapenem susceptibility in klebsiella pneumoniae carbapenemase-producing k pneumoniae: a case report and review of literature
topic ID Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493938/
https://www.ncbi.nlm.nih.gov/pubmed/28685153
http://dx.doi.org/10.1093/ofid/ofx101
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