Cargando…

Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population

There are only a few published studies related to the population-based etiology of hypopituitarism. New risks for developing hypopituitarism have been recognized in the last 10 years. Aim. To present data regarding the etiology of hypopituitarism collected in a tertiary center over the last decade....

Descripción completa

Detalles Bibliográficos
Autores principales: Doknić, M., Pekić, S., Miljić, D., Soldatović, I., Popović, V., Stojanović, M., Petakov, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494080/
https://www.ncbi.nlm.nih.gov/pubmed/28702053
http://dx.doi.org/10.1155/2017/6969286
_version_ 1783247613360865280
author Doknić, M.
Pekić, S.
Miljić, D.
Soldatović, I.
Popović, V.
Stojanović, M.
Petakov, M.
author_facet Doknić, M.
Pekić, S.
Miljić, D.
Soldatović, I.
Popović, V.
Stojanović, M.
Petakov, M.
author_sort Doknić, M.
collection PubMed
description There are only a few published studies related to the population-based etiology of hypopituitarism. New risks for developing hypopituitarism have been recognized in the last 10 years. Aim. To present data regarding the etiology of hypopituitarism collected in a tertiary center over the last decade. This is a cross-sectional database study. Patients and Methods. We included 512 patients (pts) with hypopituitarism, with a mean age of 45.9 ± 1.7 yrs (range: 18–82; male: 57.9%). Results. Nonfunctional pituitary adenomas were presented in 205 pts (40.5%), congenital causes in 74 pts (14.6%), while acromegaly and prolactinomas were presented in 37 (7.2%) and 36 (7.0%) patients, respectively. Craniopharyngiomas were detected in 30 pts (5.9%), and head trauma due to trauma brain injury-TBI and subarachnoid hemorrhage-SAH in 27 pts (5.4%). Survivors of hemorrhagic fever with renal syndrome (HFRS) and those with previous cranial irradiation were presented in the same frequency (18 pts, 3.5% each). Conclusion. The most common causes of hypopituitarism in our database are pituitary adenomas. Increased awareness of the other causes of pituitary dysfunction, such as congenital, head trauma, extrapituitary cranial irradiation, and infections, is the reason for a higher frequency of these etiologies of hypopituitarism in the presented database.
format Online
Article
Text
id pubmed-5494080
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-54940802017-07-12 Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population Doknić, M. Pekić, S. Miljić, D. Soldatović, I. Popović, V. Stojanović, M. Petakov, M. Int J Endocrinol Research Article There are only a few published studies related to the population-based etiology of hypopituitarism. New risks for developing hypopituitarism have been recognized in the last 10 years. Aim. To present data regarding the etiology of hypopituitarism collected in a tertiary center over the last decade. This is a cross-sectional database study. Patients and Methods. We included 512 patients (pts) with hypopituitarism, with a mean age of 45.9 ± 1.7 yrs (range: 18–82; male: 57.9%). Results. Nonfunctional pituitary adenomas were presented in 205 pts (40.5%), congenital causes in 74 pts (14.6%), while acromegaly and prolactinomas were presented in 37 (7.2%) and 36 (7.0%) patients, respectively. Craniopharyngiomas were detected in 30 pts (5.9%), and head trauma due to trauma brain injury-TBI and subarachnoid hemorrhage-SAH in 27 pts (5.4%). Survivors of hemorrhagic fever with renal syndrome (HFRS) and those with previous cranial irradiation were presented in the same frequency (18 pts, 3.5% each). Conclusion. The most common causes of hypopituitarism in our database are pituitary adenomas. Increased awareness of the other causes of pituitary dysfunction, such as congenital, head trauma, extrapituitary cranial irradiation, and infections, is the reason for a higher frequency of these etiologies of hypopituitarism in the presented database. Hindawi 2017 2017-06-18 /pmc/articles/PMC5494080/ /pubmed/28702053 http://dx.doi.org/10.1155/2017/6969286 Text en Copyright © 2017 M. Doknić et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Doknić, M.
Pekić, S.
Miljić, D.
Soldatović, I.
Popović, V.
Stojanović, M.
Petakov, M.
Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population
title Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population
title_full Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population
title_fullStr Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population
title_full_unstemmed Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population
title_short Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population
title_sort etiology of hypopituitarism in adult patients: the experience of a single center database in the serbian population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494080/
https://www.ncbi.nlm.nih.gov/pubmed/28702053
http://dx.doi.org/10.1155/2017/6969286
work_keys_str_mv AT doknicm etiologyofhypopituitarisminadultpatientstheexperienceofasinglecenterdatabaseintheserbianpopulation
AT pekics etiologyofhypopituitarisminadultpatientstheexperienceofasinglecenterdatabaseintheserbianpopulation
AT miljicd etiologyofhypopituitarisminadultpatientstheexperienceofasinglecenterdatabaseintheserbianpopulation
AT soldatovici etiologyofhypopituitarisminadultpatientstheexperienceofasinglecenterdatabaseintheserbianpopulation
AT popovicv etiologyofhypopituitarisminadultpatientstheexperienceofasinglecenterdatabaseintheserbianpopulation
AT stojanovicm etiologyofhypopituitarisminadultpatientstheexperienceofasinglecenterdatabaseintheserbianpopulation
AT petakovm etiologyofhypopituitarisminadultpatientstheexperienceofasinglecenterdatabaseintheserbianpopulation