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Mathematical Simulation of Transport Kinetics of Tumor-Imaging Radiopharmaceutical (99m)Tc-MIBI

The proposed model describes in a quality way the process of tumor-imaging radiopharmaceutical (99m)Tc-MIBI distribution with taking into account radiopharmaceutical accumulation, elimination, and radioactive decay. The dependencies of concentration versus the time are analyzed. The model can be eas...

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Detalles Bibliográficos
Autores principales: Shevtsova, O. N., Shevtsova, V. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494117/
https://www.ncbi.nlm.nih.gov/pubmed/28702073
http://dx.doi.org/10.1155/2017/2414878
Descripción
Sumario:The proposed model describes in a quality way the process of tumor-imaging radiopharmaceutical (99m)Tc-MIBI distribution with taking into account radiopharmaceutical accumulation, elimination, and radioactive decay. The dependencies of concentration versus the time are analyzed. The model can be easily tested by the concentration data of the radioactive pharmaceuticals in the blood measured at early time point and late time point of the scanning, and the obtained data can be used for determination of the washout rate coefficient which is one of the existing oncology diagnostics methods.