Single ocular injection of a sustained-release anti-VEGF delivers 6 months pharmacokinetics and efficacy in a primate laser CNV model

A potent anti-vascular endothelial growth factor (VEGF) biologic and a compatible delivery system were co-evaluated for protection against wet age-related macular degeneration (AMD) over a 6month period following a single intravitreal (IVT) injection. The anti-VEGF molecule is dimeric, containing tw...

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Detalles Bibliográficos
Autores principales: Adamson, Peter, Wilde, Thomas, Dobrzynski, Eric, Sychterz, Caroline, Polsky, Rodd, Kurali, Edit, Haworth, Richard, Tang, Chi-Man, Korczynska, Justyna, Cook, Fiona, Papanicolaou, Irene, Tsikna, Lemy, Roberts, Chris, Hughes-Thomas, Zoe, Walford, James, Gibson, Daniel, Warrack, John, Smal, Jos, Verrijk, Ruud, Miller, Paul E., Nork, T. Michael, Prusakiewicz, Jeffery, Streit, Timothy, Sorden, Steven, Struble, Craig, Christian, Brian, Catchpole, Ian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494198/
https://www.ncbi.nlm.nih.gov/pubmed/27810558
http://dx.doi.org/10.1016/j.jconrel.2016.10.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494198/
https://www.ncbi.nlm.nih.gov/pubmed/27810558
http://dx.doi.org/10.1016/j.jconrel.2016.10.026

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