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Transposon-mediated generation of targeting vectors for the production of gene knockouts
Vectors used for gene targeting experiments usually consist of a selectable marker flanked by two regions of homology to the targeted gene. In a homologous recombination event, the selectable marker replaces an essential element of the target gene rendering it inactive. Other applications of gene ta...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC549422/ https://www.ncbi.nlm.nih.gov/pubmed/15699181 http://dx.doi.org/10.1093/nar/gni014 |