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Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma

BACKGROUND: Ubiquitin specific peptidase 14 (USP14), a deubiquitinating enzyme, has been documented as a key element to regulate the proteolysis function of proteasomes and an attractive therapeutic target for several cancers. Herein, we elucidate the role of USP14 in predicting the prognosis of pat...

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Autores principales: Zhang, Baozhu, Li, Mengqing, Huang, Pinzhu, Guan, Xin‐Yuan, Zhu, Ying‐Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494452/
https://www.ncbi.nlm.nih.gov/pubmed/28509417
http://dx.doi.org/10.1111/1759-7714.12453
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author Zhang, Baozhu
Li, Mengqing
Huang, Pinzhu
Guan, Xin‐Yuan
Zhu, Ying‐Hui
author_facet Zhang, Baozhu
Li, Mengqing
Huang, Pinzhu
Guan, Xin‐Yuan
Zhu, Ying‐Hui
author_sort Zhang, Baozhu
collection PubMed
description BACKGROUND: Ubiquitin specific peptidase 14 (USP14), a deubiquitinating enzyme, has been documented as a key element to regulate the proteolysis function of proteasomes and an attractive therapeutic target for several cancers. Herein, we elucidate the role of USP14 in predicting the prognosis of patients with esophageal squamous cell carcinoma (ESCC). METHODS: USP14 expression was detected in ESCC tissues and matched adjacent non‐tumorous tissues by quantitative real‐time reverse transcription‐PCR and immunohistochemistry. Kaplan–Meier survival analysis was used to assess the correlation between USP14 expression and prognosis in ESCC patients. Univariate and multivariate analysis was conducted with a Cox proportional hazards model to determine whether USP14 is an independent prognostic factor. RESULT: Overexpression of USP14 was observed in approximately 60% of tested ESCC samples compared to their paired non‐tumor esophageal tissues at both RNA and protein levels, and was significantly associated with distant metastasis (P = 0.001). Kaplan–Meier analysis showed that USP14 overexpression was related to poorer overall patient survival. Univariate and multivariate analyses demonstrated that USP14 was an independent risk factor for overall survival. CONCLUSION: The findings in this study suggest that USP14 could be used as a potential prognostic marker for ESCC patients.
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spelling pubmed-54944522017-07-05 Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma Zhang, Baozhu Li, Mengqing Huang, Pinzhu Guan, Xin‐Yuan Zhu, Ying‐Hui Thorac Cancer Original Articles BACKGROUND: Ubiquitin specific peptidase 14 (USP14), a deubiquitinating enzyme, has been documented as a key element to regulate the proteolysis function of proteasomes and an attractive therapeutic target for several cancers. Herein, we elucidate the role of USP14 in predicting the prognosis of patients with esophageal squamous cell carcinoma (ESCC). METHODS: USP14 expression was detected in ESCC tissues and matched adjacent non‐tumorous tissues by quantitative real‐time reverse transcription‐PCR and immunohistochemistry. Kaplan–Meier survival analysis was used to assess the correlation between USP14 expression and prognosis in ESCC patients. Univariate and multivariate analysis was conducted with a Cox proportional hazards model to determine whether USP14 is an independent prognostic factor. RESULT: Overexpression of USP14 was observed in approximately 60% of tested ESCC samples compared to their paired non‐tumor esophageal tissues at both RNA and protein levels, and was significantly associated with distant metastasis (P = 0.001). Kaplan–Meier analysis showed that USP14 overexpression was related to poorer overall patient survival. Univariate and multivariate analyses demonstrated that USP14 was an independent risk factor for overall survival. CONCLUSION: The findings in this study suggest that USP14 could be used as a potential prognostic marker for ESCC patients. John Wiley & Sons Australia, Ltd 2017-05-16 2017-07 /pmc/articles/PMC5494452/ /pubmed/28509417 http://dx.doi.org/10.1111/1759-7714.12453 Text en © 2017 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Zhang, Baozhu
Li, Mengqing
Huang, Pinzhu
Guan, Xin‐Yuan
Zhu, Ying‐Hui
Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma
title Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma
title_full Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma
title_fullStr Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma
title_full_unstemmed Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma
title_short Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma
title_sort overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494452/
https://www.ncbi.nlm.nih.gov/pubmed/28509417
http://dx.doi.org/10.1111/1759-7714.12453
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