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DOK7 gene therapy enhances motor activity and life span in ALS model mice

Amyotrophic lateral sclerosis (ALS) is a progressive, multifactorial motor neurodegenerative disease with severe muscle atrophy. The glutamate release inhibitor riluzole is the only medication approved by the FDA, and prolongs patient life span by a few months, testifying to a strong need for new tr...

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Detalles Bibliográficos
Autores principales: Miyoshi, Sadanori, Tezuka, Tohru, Arimura, Sumimasa, Tomono, Taro, Okada, Takashi, Yamanashi, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494517/
https://www.ncbi.nlm.nih.gov/pubmed/28490573
http://dx.doi.org/10.15252/emmm.201607298