Colorectal cancer‐initiating cells caught in the act

Our increased awareness of the clonal organization of many hematological and solid cancers has dramatically changed our view on the design of novel therapeutic approaches for cancer. Tumor‐initiating cells (TIC) (a.k.a. cancer stem cells) are on the apex in this hierarchy and can self‐renew and diff...

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Detalles Bibliográficos
Autores principales: Dieter, Sebastian M, Glimm, Hanno, Ball, Claudia R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494518/
https://www.ncbi.nlm.nih.gov/pubmed/28559443
http://dx.doi.org/10.15252/emmm.201707858
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author Dieter, Sebastian M
Glimm, Hanno
Ball, Claudia R
author_facet Dieter, Sebastian M
Glimm, Hanno
Ball, Claudia R
author_sort Dieter, Sebastian M
collection PubMed
description Our increased awareness of the clonal organization of many hematological and solid cancers has dramatically changed our view on the design of novel therapeutic approaches for cancer. Tumor‐initiating cells (TIC) (a.k.a. cancer stem cells) are on the apex in this hierarchy and can self‐renew and differentiate, thereby continuously fueling tumor growth and metastasis formation. This process was previously thought to be unidirectional. Self‐renewing TIC therefore represent highly attractive targets for therapeutic intervention.
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spelling pubmed-54945182017-07-05 Colorectal cancer‐initiating cells caught in the act Dieter, Sebastian M Glimm, Hanno Ball, Claudia R EMBO Mol Med News & Views Our increased awareness of the clonal organization of many hematological and solid cancers has dramatically changed our view on the design of novel therapeutic approaches for cancer. Tumor‐initiating cells (TIC) (a.k.a. cancer stem cells) are on the apex in this hierarchy and can self‐renew and differentiate, thereby continuously fueling tumor growth and metastasis formation. This process was previously thought to be unidirectional. Self‐renewing TIC therefore represent highly attractive targets for therapeutic intervention. John Wiley and Sons Inc. 2017-05-30 2017-07 /pmc/articles/PMC5494518/ /pubmed/28559443 http://dx.doi.org/10.15252/emmm.201707858 Text en © 2017 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the Creative Commons Attribution 4.0 (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle News & Views
Dieter, Sebastian M
Glimm, Hanno
Ball, Claudia R
Colorectal cancer‐initiating cells caught in the act
title Colorectal cancer‐initiating cells caught in the act
title_full Colorectal cancer‐initiating cells caught in the act
title_fullStr Colorectal cancer‐initiating cells caught in the act
title_full_unstemmed Colorectal cancer‐initiating cells caught in the act
title_short Colorectal cancer‐initiating cells caught in the act
title_sort colorectal cancer‐initiating cells caught in the act
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494518/
https://www.ncbi.nlm.nih.gov/pubmed/28559443
http://dx.doi.org/10.15252/emmm.201707858
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