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A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease

Multiple factors, including amyloid-β (Aβ), metals, and reactive oxygen species (ROS), are involved in the development of Alzheimer's disease (AD). Metal ions can interact with Aβ species generating toxic oligomers and ROS in vitro; however, the involvement of metal–Aβ complexes in AD pathology...

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Detalles Bibliográficos
Autores principales:	Beck, Michael W., Oh, Shin Bi, Kerr, Richard A., Lee, Hyuck Jin, Kim, So Hee, Kim, Sujeong, Jang, Milim, Ruotolo, Brandon T., Lee, Joo-Yong, Lim, Mi Hee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2015
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494539/ https://www.ncbi.nlm.nih.gov/pubmed/28706643 http://dx.doi.org/10.1039/c4sc03239j

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