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Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies
Radiation-induced lung injury (RILI) remains a major obstacle for thoracic radiotherapy for the treatment of lung cancer, esophageal cancer and lymphoma. It is the principal dose-limiting complication, and can markedly impair the therapeutic ratio as well as a patient's quality of life. The cur...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494764/ https://www.ncbi.nlm.nih.gov/pubmed/28693198 http://dx.doi.org/10.3892/ol.2017.6268 |
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author | Deng, Guodong Liang, Ning Xie, Jian Luo, Hui Qiao, Lili Zhang, Jingxin Wang, Dawei Zhang, Jiandong |
author_facet | Deng, Guodong Liang, Ning Xie, Jian Luo, Hui Qiao, Lili Zhang, Jingxin Wang, Dawei Zhang, Jiandong |
author_sort | Deng, Guodong |
collection | PubMed |
description | Radiation-induced lung injury (RILI) remains a major obstacle for thoracic radiotherapy for the treatment of lung cancer, esophageal cancer and lymphoma. It is the principal dose-limiting complication, and can markedly impair the therapeutic ratio as well as a patient's quality of life. The current review presents the relevant concepts associated with RILI, including the pathogenic mechanisms and the potential treatment strategies, so as to achieve a general understanding of this issue. RILI comprises an acute radiation pneumonitis phase and subsequent late lung fibrosis. The established assessment criteria are clinical manifestations, imaging changes and the necessity for medical assistance. Risk factors are also considered in order to optimize treatment planning. Due to the underlying molecular mechanisms of RILI, the present review also discusses several targeted pharmacological approaches for its treatment, as well as corticosteroid therapy. |
format | Online Article Text |
id | pubmed-5494764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-54947642017-07-07 Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies Deng, Guodong Liang, Ning Xie, Jian Luo, Hui Qiao, Lili Zhang, Jingxin Wang, Dawei Zhang, Jiandong Oncol Lett Review Radiation-induced lung injury (RILI) remains a major obstacle for thoracic radiotherapy for the treatment of lung cancer, esophageal cancer and lymphoma. It is the principal dose-limiting complication, and can markedly impair the therapeutic ratio as well as a patient's quality of life. The current review presents the relevant concepts associated with RILI, including the pathogenic mechanisms and the potential treatment strategies, so as to achieve a general understanding of this issue. RILI comprises an acute radiation pneumonitis phase and subsequent late lung fibrosis. The established assessment criteria are clinical manifestations, imaging changes and the necessity for medical assistance. Risk factors are also considered in order to optimize treatment planning. Due to the underlying molecular mechanisms of RILI, the present review also discusses several targeted pharmacological approaches for its treatment, as well as corticosteroid therapy. D.A. Spandidos 2017-07 2017-05-26 /pmc/articles/PMC5494764/ /pubmed/28693198 http://dx.doi.org/10.3892/ol.2017.6268 Text en Copyright: © Deng et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Deng, Guodong Liang, Ning Xie, Jian Luo, Hui Qiao, Lili Zhang, Jingxin Wang, Dawei Zhang, Jiandong Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies |
title | Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies |
title_full | Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies |
title_fullStr | Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies |
title_full_unstemmed | Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies |
title_short | Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies |
title_sort | pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494764/ https://www.ncbi.nlm.nih.gov/pubmed/28693198 http://dx.doi.org/10.3892/ol.2017.6268 |
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