Cargando…

Apogossypolone induces apoptosis and autophagy in nasopharyngeal carcinoma cells in an in vitro and in vivo study

Nasopharyngeal carcinoma (NPC) has a high incidence and mortality rate, particularly in Southern China. Apogossypolone (ApoG2) is a novel derivative of gossypol with antitumor activity and less toxicity. The human NPC CNE-2 cell line was studied in the in vitro model; whilst 4 week-old male nude mic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Ruinian, Chen, Kexu, Zhang, Yu, Huang, Jie, Shi, Fengrong, Wu, Gang, Wang, Senming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494797/ https://www.ncbi.nlm.nih.gov/pubmed/28693230 http://dx.doi.org/10.3892/ol.2017.6176

Ejemplares similares

Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo
por: ZHANG, XIANQING, et al.
Publicado: (2014)

Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo
por: Zhang, Xianqing, et al.
Publicado: (2018)

The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma cells
por: Cheng, P, et al.
Publicado: (2013)

The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular cells
por: Cheng, P, et al.
Publicado: (2013)

Theaflavin promoted apoptosis in nasopharyngeal carcinoma unexpectedly via inducing autophagy in vitro
por: Xu, Jing, et al.
Publicado: (2022)

Role of Taxane and Anthracycline Combination Regimens in the Management of Advanced Breast Cancer: A Meta-Analysis of Randomized Trials
por: Zheng, Ruinian, et al.
Publicado: (2015)

Apogossypolone targets mitochondria and light enhances its anticancer activity by stimulating generation of singlet oxygen and reactive oxygen species
por: Hu, Zhe-Yu, et al.
Publicado: (2011)

PNCK depletion inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells in vitro and in vivo
por: Xu, Yuanji, et al.
Publicado: (2019)

Curcumin enhances the antitumor effect of ABT-737 via activation of the ROS-ASK1-JNK pathway in hepatocellular carcinoma cells
por: ZHENG, RUINIAN, et al.
Publicado: (2016)

Combination of the natural compound Periplocin and TRAIL induce esophageal squamous cell carcinoma apoptosis in vitro and in vivo: Implication in anticancer therapy
por: Han, Lujuan, et al.
Publicado: (2019)

Phosphatidylinositol 3-kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo
por: Jiang, Hanguo, et al.
Publicado: (2010)

Apogossypolone Inhibits Cell Proliferation and Epithelial-Mesenchymal Transition in Cervical Cancer via Activating DKK3
por: Li, Yuling, et al.
Publicado: (2022)

Selenite-induced autophagy antagonizes apoptosis in colorectal cancer cells in vitro and in vivo
por: YANG, YANG, et al.
Publicado: (2016)

miR-331-3p Inhibits Proliferation and Promotes Apoptosis of Nasopharyngeal Carcinoma Cells by Targeting elf4B-PI3K-AKT Pathway
por: Xuefang, Zhang, et al.
Publicado: (2020)

An Optically Pure Apogossypolone Derivative as Potent Pan-Active Inhibitor of Anti-Apoptotic Bcl-2 Family Proteins
por: Wei, Jun, et al.
Publicado: (2011)

Polyphyllin G induce apoptosis and autophagy in human nasopharyngeal cancer cells by modulation of AKT and mitogen-activated protein kinase pathways in vitro and in vivo
por: Chen, Jui-Chieh, et al.
Publicado: (2016)

Mobilization of Intracellular Copper by Gossypol and Apogossypolone Leads to Reactive Oxygen Species-Mediated Cell Death: Putative Anticancer Mechanism
por: Zubair, Haseeb, et al.
Publicado: (2016)

Isokotomolide A from Cinnamomum kotoense Induce Melanoma Autophagy and Apoptosis In Vivo and In Vitro
por: Li, Jian, et al.
Publicado: (2020)

2,5-dimethyl celecoxib induces apoptosis and autophagy via activation of ROS/JNK axis in nasopharyngeal carcinoma cells
por: Tan, Tan, et al.
Publicado: (2021)

Convallatoxin, a Dual Inducer of Autophagy and Apoptosis, Inhibits Angiogenesis In Vitro and In Vivo
por: Yang, Seung Ya, et al.
Publicado: (2014)

N6-(2-hydroxyethyl)-Adenosine Induces Apoptosis via ER Stress and Autophagy of Gastric Carcinoma Cells In Vitro and In Vivo
por: Xie, Hongqing, et al.
Publicado: (2020)

MTA1 promotes nasopharyngeal carcinoma growth in vitro and in vivo
por: Song, Qingcui, et al.
Publicado: (2013)

Baicalein Exerts Anticancer Effect in Nasopharyngeal Carcinoma In Vitro and In Vivo
por: Guo, Jiandong, et al.
Publicado: (2019)

Inhibition of autophagy by 3-MA enhances endoplasmic reticulum stress-induced apoptosis in human nasopharyngeal carcinoma cells
por: SONG, LELE, et al.
Publicado: (2013)

In vivo and in vitro study of co-expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma()
por: Ye, Qing, et al.
Publicado: (2019)

Yu Nu Compound Regulates Autophagy and Apoptosis Through mTOR in vivo and vitro
por: He, Caigu, et al.
Publicado: (2020)

In vivo and in vitro investigation of KIN-193 anti-tumor effects on nasopharyngeal carcinoma
por: Chen, Fuhai, et al.
Publicado: (2020)

Blockage of Autophagy Increases Timosaponin AIII-Induced Apoptosis of Glioma Cells In Vitro and In Vivo
por: Lee, Chu-Che, et al.
Publicado: (2022)

Mukonal Inhibits Cell Proliferation, Alters Mitochondrial Membrane Potential and Induces Apoptosis and Autophagy in Human CNE1 Nasopharyngeal Carcinoma Cells
por: Guo, Yingyuan, et al.
Publicado: (2019)

Osthole sensitizes with radiotherapy to suppress tumorigenesis of human nasopharyngeal carcinoma in vitro and in vivo
por: Peng, Lin, et al.
Publicado: (2018)

Cellular Redox Status Regulates Emodin-Induced Radiosensitization of Nasopharyngeal Carcinoma Cells In Vitro and In Vivo
por: Hou, Huaxin, et al.
Publicado: (2013)

Retracted: Mukonal Inhibits Cell Proliferation, Alters Mitochondrial Membrane Potential and Induces Apoptosis and Autophagy in Human CNE1 Nasopharyngeal Carcinoma Cells
por: Guo, Yingyuan, et al.
Publicado: (2021)

Usnic Acid Induces Cycle Arrest, Apoptosis, and Autophagy in Gastric Cancer Cells In Vitro and In Vivo
por: Geng, Xiaoge, et al.
Publicado: (2018)

Radiosensitization of Clioquinol Combined with Zinc in the Nasopharyngeal Cancer Stem-like Cells by Inhibiting Autophagy in Vitro and in Vivo
por: Ke, Yuan, et al.
Publicado: (2020)

Autophagy Protects against Palmitic Acid-Induced Apoptosis in Podocytes in vitro
por: Jiang, Xu-shun, et al.
Publicado: (2017)

Efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in nasopharyngeal carcinoma in vitro and in vivo
por: Huang, Yan, et al.
Publicado: (2018)

Capsaicin Induces Autophagy and Apoptosis in Human Nasopharyngeal Carcinoma Cells by Downregulating the PI3K/AKT/mTOR Pathway
por: Lin, Yu-Tsai, et al.
Publicado: (2017)

Betulinic acid induces apoptosis and suppresses metastasis in hepatocellular carcinoma cell lines in vitro and in vivo
por: Wang, Wei, et al.
Publicado: (2018)

ISL Induces Apoptosis and Autophagy in Hepatocellular Carcinoma via Downregulation of PI3K/AKT/mTOR Pathway in vivo and in vitro
por: Song, Lei, et al.
Publicado: (2020)

Chemotherapeutic effect of a novel temozolomide analog on nasopharyngeal carcinoma in vitro and in vivo
por: Chen, Thomas C., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_6ru7iattskc28grgf0e6mn0oir