Ultrasound-guided drug delivery in cancer

Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues while reducing systemic dose and toxicity. The mechanism behind enhanced delivery of therapeutics is so...

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Detalles Bibliográficos
Autores principales: Mullick Chowdhury, Sayan, Lee, Taehwa, Willmann, Jürgen K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Ultrasound in Medicine 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494871/
https://www.ncbi.nlm.nih.gov/pubmed/28607323
http://dx.doi.org/10.14366/usg.17021
Descripción
Sumario:Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues while reducing systemic dose and toxicity. The mechanism behind enhanced delivery of therapeutics is sonoporation, the formation of openings in the vasculature, induced by ultrasound-triggered oscillations and destruction of microbubbles. In this review, progress and challenges of USMB mediated drug delivery are summarized, with special focus on cancer therapy.

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