Ultrasound-guided drug delivery in cancer

Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues while reducing systemic dose and toxicity. The mechanism behind enhanced delivery of therapeutics is so...

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Autores principales: Mullick Chowdhury, Sayan, Lee, Taehwa, Willmann, Jürgen K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Ultrasound in Medicine 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494871/
https://www.ncbi.nlm.nih.gov/pubmed/28607323
http://dx.doi.org/10.14366/usg.17021
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author Mullick Chowdhury, Sayan
Lee, Taehwa
Willmann, Jürgen K.
author_facet Mullick Chowdhury, Sayan
Lee, Taehwa
Willmann, Jürgen K.
author_sort Mullick Chowdhury, Sayan
collection PubMed
description Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues while reducing systemic dose and toxicity. The mechanism behind enhanced delivery of therapeutics is sonoporation, the formation of openings in the vasculature, induced by ultrasound-triggered oscillations and destruction of microbubbles. In this review, progress and challenges of USMB mediated drug delivery are summarized, with special focus on cancer therapy.
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spelling pubmed-54948712017-07-05 Ultrasound-guided drug delivery in cancer Mullick Chowdhury, Sayan Lee, Taehwa Willmann, Jürgen K. Ultrasonography Review Article Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues while reducing systemic dose and toxicity. The mechanism behind enhanced delivery of therapeutics is sonoporation, the formation of openings in the vasculature, induced by ultrasound-triggered oscillations and destruction of microbubbles. In this review, progress and challenges of USMB mediated drug delivery are summarized, with special focus on cancer therapy. Korean Society of Ultrasound in Medicine 2017-07 2017-05-01 /pmc/articles/PMC5494871/ /pubmed/28607323 http://dx.doi.org/10.14366/usg.17021 Text en Copyright © 2017 Korean Society of Ultrasound in Medicine (KSUM) This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mullick Chowdhury, Sayan
Lee, Taehwa
Willmann, Jürgen K.
Ultrasound-guided drug delivery in cancer
title Ultrasound-guided drug delivery in cancer
title_full Ultrasound-guided drug delivery in cancer
title_fullStr Ultrasound-guided drug delivery in cancer
title_full_unstemmed Ultrasound-guided drug delivery in cancer
title_short Ultrasound-guided drug delivery in cancer
title_sort ultrasound-guided drug delivery in cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494871/
https://www.ncbi.nlm.nih.gov/pubmed/28607323
http://dx.doi.org/10.14366/usg.17021
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