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The role of eukaryotic translation initiation factor 6 in tumors
Eukaryotic translation initiation factor 6 (eIF6) affects the maturation of 60S ribosomal subunits. Found in yeast and mammalian cells, eIF6 is primarily located in the cytoplasm of mammalian cells. Emerging evidence has demonstrated that the dysregulated expression of eIF6 is important in several t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494901/ https://www.ncbi.nlm.nih.gov/pubmed/28693127 http://dx.doi.org/10.3892/ol.2017.6161 |
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author | Zhu, Wei Li, Gui Xian Chen, Hong Lang Liu, Xing Yan |
author_facet | Zhu, Wei Li, Gui Xian Chen, Hong Lang Liu, Xing Yan |
author_sort | Zhu, Wei |
collection | PubMed |
description | Eukaryotic translation initiation factor 6 (eIF6) affects the maturation of 60S ribosomal subunits. Found in yeast and mammalian cells, eIF6 is primarily located in the cytoplasm of mammalian cells. Emerging evidence has demonstrated that the dysregulated expression of eIF6 is important in several types of human cancer, including head and neck carcinoma, colorectal cancer, non-small cell lung cancer and ovarian serous adenocarcinoma. However, the molecular mechanisms by which eIF6 functions during tumor formation and progression remain elusive. The present review focuses on recent progress in terms of the mechanisms and functions of eIF6 in human tumorigenesis or cancer cell lines, along with the signal transduction pathways in which this novel translation initiation factor may participate. Oncogenic Ras activates Notch-1 and promotes transcription of eIF6 via a recombining binding protein suppressor of Hairless-dependent mechanism. In addition, overexpression of eIF6 results in aberrant activation of the Wnt/β-catenin signaling pathway. Similarly, overexpressed eIF6 regulates its downstream modulator, cell division control protein 42, which in turn affects oncogenesis. Finally, the potential of eIF6 as a biomarker for diagnosis of cancer is also discussed in the present review. |
format | Online Article Text |
id | pubmed-5494901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-54949012017-07-07 The role of eukaryotic translation initiation factor 6 in tumors Zhu, Wei Li, Gui Xian Chen, Hong Lang Liu, Xing Yan Oncol Lett Review Eukaryotic translation initiation factor 6 (eIF6) affects the maturation of 60S ribosomal subunits. Found in yeast and mammalian cells, eIF6 is primarily located in the cytoplasm of mammalian cells. Emerging evidence has demonstrated that the dysregulated expression of eIF6 is important in several types of human cancer, including head and neck carcinoma, colorectal cancer, non-small cell lung cancer and ovarian serous adenocarcinoma. However, the molecular mechanisms by which eIF6 functions during tumor formation and progression remain elusive. The present review focuses on recent progress in terms of the mechanisms and functions of eIF6 in human tumorigenesis or cancer cell lines, along with the signal transduction pathways in which this novel translation initiation factor may participate. Oncogenic Ras activates Notch-1 and promotes transcription of eIF6 via a recombining binding protein suppressor of Hairless-dependent mechanism. In addition, overexpression of eIF6 results in aberrant activation of the Wnt/β-catenin signaling pathway. Similarly, overexpressed eIF6 regulates its downstream modulator, cell division control protein 42, which in turn affects oncogenesis. Finally, the potential of eIF6 as a biomarker for diagnosis of cancer is also discussed in the present review. D.A. Spandidos 2017-07 2017-05-12 /pmc/articles/PMC5494901/ /pubmed/28693127 http://dx.doi.org/10.3892/ol.2017.6161 Text en Copyright: © Zhu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Zhu, Wei Li, Gui Xian Chen, Hong Lang Liu, Xing Yan The role of eukaryotic translation initiation factor 6 in tumors |
title | The role of eukaryotic translation initiation factor 6 in tumors |
title_full | The role of eukaryotic translation initiation factor 6 in tumors |
title_fullStr | The role of eukaryotic translation initiation factor 6 in tumors |
title_full_unstemmed | The role of eukaryotic translation initiation factor 6 in tumors |
title_short | The role of eukaryotic translation initiation factor 6 in tumors |
title_sort | role of eukaryotic translation initiation factor 6 in tumors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494901/ https://www.ncbi.nlm.nih.gov/pubmed/28693127 http://dx.doi.org/10.3892/ol.2017.6161 |
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