Cargando…

Acute myeloid leukemia with t(3;21)(q26.2;q22) developing following low-dose methotrexate therapy for rheumatoid arthritis and expressing two AML1/MDS1/EVI1 fusion proteins: A case report

The t(3;21)(q26.2;q22) translocation is a rare chromosomal abnormality exhibited almost exclusively in therapy-related myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) or in the blastic crisis phase of chronic myelogenous leukemia, which results in the fusion of the runt related transcrip...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tanaka, Keisuke, Oshikawa, Gaku, Akiyama, Hiroki, Ishida, Shinya, Nagao, Toshikage, Yamamoto, Masahide, Miura, Osamu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494941/ https://www.ncbi.nlm.nih.gov/pubmed/28693140 http://dx.doi.org/10.3892/ol.2017.6151

Ejemplares similares

Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including newly established PVTL-2
por: Ishida, Shinya, et al.
Publicado: (2018)

Clinical and Genomic Profiles of Korean Patients with MECOM Rearrangement and the t(3;21)(q26.2;q22.1) Translocation
por: Lee, Jikyo, et al.
Publicado: (2022)

RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML
por: Loke, Justin, et al.
Publicado: (2017)

PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positive leukemia cells
por: WU, NAN, et al.
Publicado: (2012)

Proliferation and Survival Signaling from Both Jak2-V617F and Lyn Involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 Cell Line Newly Established from Acute Myeloid Leukemia Transformed from Polycythemia Vera
por: Nagao, Toshikage, et al.
Publicado: (2014)

Inhibition of the PI3K/Akt/GSK3 Pathway Downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD Downregulates DNA Damage-Induced Chk1 Activation as Well as G2/M Arrest and Prominently Enhances Induction of Apoptosis
por: Kurosu, Tetsuya, et al.
Publicado: (2013)

DNA Damage Stress and Inhibition of Jak2-V617F Cause Its Degradation and Synergistically Induce Apoptosis through Activation of GSK3β
por: Nagao, Toshikage, et al.
Publicado: (2011)

FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia
por: Nogami, Ayako, et al.
Publicado: (2015)

Emergence of t(3;21)(q26.2;q22) during eltrombopag treatment in a patient with relapsed aplastic anemia who received chemotherapy for angioimmunoblastic T-cell lymphoma
por: Nakamura, Fumi, et al.
Publicado: (2022)

IRAK1: oncotarget in MDS and AML
por: Beverly, Levi J., et al.
Publicado: (2014)

Characteristics and clinical outcomes of patients with acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2)
por: Richard-Carpentier, Guillaume, et al.
Publicado: (2023)

Cytogenomic characterization of 1q43q44 deletion associated with 4q32.1q35.2 duplication and phenotype correlation
por: Mohamed, A. M., et al.
Publicado: (2018)

An Interstitial Deletion at 10q26.2q26.3
por: Iourov, Ivan Y., et al.
Publicado: (2014)

Chronic iron exposure and c-Myc/H-ras-mediated transformation in fallopian tube cells alter the expression of EVI1, amplified at 3q26.2 in ovarian cancer
por: Rockfield, Stephanie, et al.
Publicado: (2019)

A new mosaic der(18)t(1;18)(q32.1;q21.3) with developmental delay and facial dysmorphism
por: Choi, Young-Jin, et al.
Publicado: (2016)

A novel chromosome 2q24.3‐q32.1 microdeletion in a fetus with multiple malformations
por: Zhu, Mianmian, et al.
Publicado: (2022)

Targeting ncRNAs in the 3q26.2 amplicon
por: Chaluvally-Raghavan, Pradeep, et al.
Publicado: (2015)

Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1
por: Cai, Qiuyin, et al.
Publicado: (2014)

Establishment of an Undifferentiated Leukemia Cell Line (Kasumi‐3) with t(3;7)(q27;q22) and Activation of the EVI1 Gene
por: Asou, Hiroya, et al.
Publicado: (1996)

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia
por: Tanaka, Atsushi, et al.
Publicado: (2022)

Inherited predisposition to MDS/AML
por: Rio Machin, Ana, et al.
Publicado: (2018)

伴t(3;21)(q26;q22)髓系肿瘤临床分析
Publicado: (2019)

A standardized microarray assay for the independent gene expression markers in AML: EVI1 and BAALC
por: Brand, Jaap, et al.
Publicado: (2013)

Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21
por: Zhang, Mingfeng, et al.
Publicado: (2016)

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS
por: Krönke, Jan, et al.
Publicado: (2015)

Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33
por: Houlston, Richard S, et al.
Publicado: (2010)

Identification of Two Critically Deleted Regions within Chromosome Segment 7q35-q36 in EVI1 Deregulated Myeloid Leukemia Cell Lines
por: De Weer, An, et al.
Publicado: (2010)

miR-133 regulates Evi1 expression in AML cells as a potential therapeutic target
por: Yamamoto, Haruna, et al.
Publicado: (2016)

A critical role of epigenetic inactivation of miR-9 in EVI1(high) pediatric AML
por: Mittal, Nupur, et al.
Publicado: (2019)

Mutations and karyotype in myelodysplastic syndromes: TP53 clusters with monosomal karyotype, RUNX1 with trisomy 21, and SF3B1 with inv(3)(q21q26.2) and del(11q)
por: Tefferi, Ayalew, et al.
Publicado: (2017)

Lenalidomide does not increase AML progression risk in RBC transfusion-dependent patients with Low- or Intermediate-1-risk MDS with del(5q): a comparative analysis
por: Kuendgen, A, et al.
Publicado: (2013)

Genome-wide association study identifies locus at chromosome 2q32.1 associated with syncope and collapse
por: Hadji-Turdeghal, Katra, et al.
Publicado: (2020)

De Novo Interstitial Microdeletion at 1q32.1 in a 10-Year-Old Boy with Developmental Delay and Dysmorphism
por: Carter, Jennifer, et al.
Publicado: (2016)

Reciprocal regulation of TWIST1 and OGT determines the decitabine efficacy in MDS/AML
por: Li, Hongjiao, et al.
Publicado: (2023)

Extended survival and reduced risk of AML progression in erythroid-responsive lenalidomide-treated patients with lower-risk del(5q) MDS
por: List, A F, et al.
Publicado: (2014)

Identification of novel candidate target genes, including EPHB3, MASP1 and SST at 3q26.2–q29 in squamous cell carcinoma of the lung
por: Kang, Ji Un, et al.
Publicado: (2009)

A 7q31.33q32.1 microdeletion including LRRC4 and GRM8 is associated with severe intellectual disability and characteristics of autism
por: Sangu, Noriko, et al.
Publicado: (2017)

A case of germline mosaicism for a 7q32.1q33 deletion in a sperm donor: consequences on pregnancy follow-up and recommendations
por: Chalas, Celine, et al.
Publicado: (2020)

Pediatric chronic myeloid leukemia with inv(3)(q21q26.2) and T lymphoblastic transformation: a case report
por: Lewen, Margaret, et al.
Publicado: (2016)

A primary pediatric acute myelomonocytic leukemia with t(3;21)(q26;q22): A case report
por: Duan, Jia-xin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3q6kafc77v4dcpbut6j6ol0c85