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Epidemiological Characteristics and Clinical Outcome of HIV-Related Tuberculosis in a Population of TB Patients in South-western Nigeria

Tuberculosis (TB) is the second leading cause of death from infectious disease globally with its impact more dramatic in resource limited settings. Individuals with human immunodeficiency virus (HIV) infection who also develop tuberculosis represent a significant challenge to TB control. This study...

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Autores principales: Olowe, Olugbenga A., Makanjuola, Olufunmilola B., Adekanmi, Adeniyi S., Adefioye, Olusola J., Olowe, Rita A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Akadémiai Kiadó 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495084/
https://www.ncbi.nlm.nih.gov/pubmed/28690879
http://dx.doi.org/10.1556/1886.2017.00003
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author Olowe, Olugbenga A.
Makanjuola, Olufunmilola B.
Adekanmi, Adeniyi S.
Adefioye, Olusola J.
Olowe, Rita A.
author_facet Olowe, Olugbenga A.
Makanjuola, Olufunmilola B.
Adekanmi, Adeniyi S.
Adefioye, Olusola J.
Olowe, Rita A.
author_sort Olowe, Olugbenga A.
collection PubMed
description Tuberculosis (TB) is the second leading cause of death from infectious disease globally with its impact more dramatic in resource limited settings. Individuals with human immunodeficiency virus (HIV) infection who also develop tuberculosis represent a significant challenge to TB control. This study was carried out to determine the prevalence of TB–HIV coinfection and pattern of infection among TB patients. We also compared treatment outcome among coinfected patients with those not coinfected. A six-year retrospective review of records of patients managed at the Tuberculosis Treatment Center of the LAUTECH Teaching Hospital, South-Western Nigeria from January 2009 to December 2014 was carried out. One hundred and five (26.3%) of the 399 TB patients seen in the study period were coinfected with HIV. About 10% of the subjects had extrapulmonary tuberculosis. Treatment failure was significantly worse among patients who had both HIV and TB compared with those who had TB only (49.5% vs. 32%, p = 0.001). Death rate was also higher in the coinfected individuals implying a poorer clinical outcome. High prevalence of TB–HIV coinfection and poor treatment outcome in this group of individuals, though predictable, calls for a more concerted effort in the management of TB–HIV coinfection.
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spelling pubmed-54950842017-07-07 Epidemiological Characteristics and Clinical Outcome of HIV-Related Tuberculosis in a Population of TB Patients in South-western Nigeria Olowe, Olugbenga A. Makanjuola, Olufunmilola B. Adekanmi, Adeniyi S. Adefioye, Olusola J. Olowe, Rita A. Eur J Microbiol Immunol (Bp) Original Article Tuberculosis (TB) is the second leading cause of death from infectious disease globally with its impact more dramatic in resource limited settings. Individuals with human immunodeficiency virus (HIV) infection who also develop tuberculosis represent a significant challenge to TB control. This study was carried out to determine the prevalence of TB–HIV coinfection and pattern of infection among TB patients. We also compared treatment outcome among coinfected patients with those not coinfected. A six-year retrospective review of records of patients managed at the Tuberculosis Treatment Center of the LAUTECH Teaching Hospital, South-Western Nigeria from January 2009 to December 2014 was carried out. One hundred and five (26.3%) of the 399 TB patients seen in the study period were coinfected with HIV. About 10% of the subjects had extrapulmonary tuberculosis. Treatment failure was significantly worse among patients who had both HIV and TB compared with those who had TB only (49.5% vs. 32%, p = 0.001). Death rate was also higher in the coinfected individuals implying a poorer clinical outcome. High prevalence of TB–HIV coinfection and poor treatment outcome in this group of individuals, though predictable, calls for a more concerted effort in the management of TB–HIV coinfection. Akadémiai Kiadó 2017-04-26 /pmc/articles/PMC5495084/ /pubmed/28690879 http://dx.doi.org/10.1556/1886.2017.00003 Text en © 2017, The Author(s) http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Olowe, Olugbenga A.
Makanjuola, Olufunmilola B.
Adekanmi, Adeniyi S.
Adefioye, Olusola J.
Olowe, Rita A.
Epidemiological Characteristics and Clinical Outcome of HIV-Related Tuberculosis in a Population of TB Patients in South-western Nigeria
title Epidemiological Characteristics and Clinical Outcome of HIV-Related Tuberculosis in a Population of TB Patients in South-western Nigeria
title_full Epidemiological Characteristics and Clinical Outcome of HIV-Related Tuberculosis in a Population of TB Patients in South-western Nigeria
title_fullStr Epidemiological Characteristics and Clinical Outcome of HIV-Related Tuberculosis in a Population of TB Patients in South-western Nigeria
title_full_unstemmed Epidemiological Characteristics and Clinical Outcome of HIV-Related Tuberculosis in a Population of TB Patients in South-western Nigeria
title_short Epidemiological Characteristics and Clinical Outcome of HIV-Related Tuberculosis in a Population of TB Patients in South-western Nigeria
title_sort epidemiological characteristics and clinical outcome of hiv-related tuberculosis in a population of tb patients in south-western nigeria
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495084/
https://www.ncbi.nlm.nih.gov/pubmed/28690879
http://dx.doi.org/10.1556/1886.2017.00003
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