CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies

Janus kinase 2 (JAK2) is a central kinase in hematopoietic stem/progenitor cells (HSPCs), and its uncontrolled activation is a prominent oncogenic driver of hematopoietic neoplasms. However, molecular mechanisms underlying the regulation of JAK2 have remained elusive. Here we report that the Casitas...

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Detalles Bibliográficos
Autores principales: Lv, Kaosheng, Jiang, Jing, Donaghy, Ryan, Riling, Christopher R., Cheng, Ying, Chandra, Vemika, Rozenova, Krasimira, An, Wei, Mohapatra, Bhopal C., Goetz, Benjamin T., Pillai, Vinodh, Han, Xu, Todd, Emily A., Jeschke, Grace R., Langdon, Wallace Y., Kumar, Suresh, Hexner, Elizabeth O., Band, Hamid, Tong, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495118/
https://www.ncbi.nlm.nih.gov/pubmed/28611190
http://dx.doi.org/10.1101/gad.297135.117

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