Cargando…

Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA

We recently identified pathogenic KIF1Bβ mutations in sympathetic nervous system malignancies that are defective in developmental apoptosis. Here we deleted KIF1Bβ in the mouse sympathetic nervous system and observed impaired sympathetic nervous function and misexpression of genes required for sympa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fell, Stuart M., Li, Shuijie, Wallis, Karin, Kock, Anna, Surova, Olga, Rraklli, Vilma, Höfig, Carolin S., Li, Wenyu, Mittag, Jens, Henriksson, Marie Arsenian, Kenchappa, Rajappa S., Holmberg, Johan, Kogner, Per, Schlisio, Susanne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495120/ https://www.ncbi.nlm.nih.gov/pubmed/28637693 http://dx.doi.org/10.1101/gad.297077.117

Ejemplares similares

XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis
por: Choo, Zhang'e, et al.
Publicado: (2016)

Aberrant splicing in neuroblastoma generates RNA-fusion transcripts and provides vulnerability to spliceosome inhibitors
por: Shi, Yao, et al.
Publicado: (2021)

Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes
por: De Preter, Katleen, et al.
Publicado: (2006)

Correction: Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes
por: De Preter, Katleen, et al.
Publicado: (2007)

Expression and activation of nuclear hormone receptors result in neuronal differentiation and favorable prognosis in neuroblastoma
por: Sainero-Alcolado, Lourdes, et al.
Publicado: (2022)

NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells
por: Ruggeri, P, et al.
Publicado: (2016)

Integrative discovery of treatments for high-risk neuroblastoma
por: Almstedt, Elin, et al.
Publicado: (2020)

Clinical and biological features of neuroblastic tumors: A comparison of neuroblastoma and ganglioneuroblastoma
por: He, Wen-Guang, et al.
Publicado: (2017)

TrkA Co-Receptors: The Janus Face of TrkA?
por: Trouvilliez, Sarah, et al.
Publicado: (2023)

Clinical relevance of TRKA expression on neuroblastoma: comparison with N-MYC amplification and CD44 expression.
por: Combaret, V., et al.
Publicado: (1997)

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors
por: Bedoya-Reina, O. C., et al.
Publicado: (2021)

Enhancing Brain Retention of a KIF11 Inhibitor Significantly Improves its Efficacy in a Mouse Model of Glioblastoma
por: Gampa, Gautham, et al.
Publicado: (2020)

TTF1 suppresses neuroblastoma growth and induces neuroblastoma differentiation by targeting TrkA and the miR-204/TrkB axis
por: Yang, Tianyou, et al.
Publicado: (2022)

Nucleofection of Rodent Neuroblasts to Study Neuroblast Migration In vitro
por: Falenta, Katarzyna, et al.
Publicado: (2013)

NGF sensitizes TrkA SH-SY5Y neuroblastoma cells to TRAIL-induced apoptosis
por: Ruggeri, P, et al.
Publicado: (2016)

Immune suppression by myeloid-derived suppressor cells, MDSCs, in MYCN-driven neuroblastoma provides a potential target for cancer immunotherapy
por: Eissler, Nina, et al.
Publicado: (2014)

Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome
por: Li, Shuijie, et al.
Publicado: (2022)

Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome
por: Li, Shuijie, et al.
Publicado: (2022)

A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons
por: Södersten, Erik, et al.
Publicado: (2018)

Author Correction: A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons
por: Södersten, Erik, et al.
Publicado: (2018)

Presence of Differentiating Neuroblasts in Bone Marrow is a Favorable Prognostic Factor for Bone Marrow Metastatic Neuroblastoma at Diagnosis
por: Park, Sang Hyuk, et al.
Publicado: (2013)

MYCN-amplified neuroblastoma maintains an aggressive and undifferentiated phenotype by deregulation of estrogen and NGF signaling
por: Dzieran, Johanna, et al.
Publicado: (2018)

ERBB3 is a marker of a ganglioneuroblastoma/ganglioneuroma-like expression profile in neuroblastic tumours
por: Wilzén, Annica, et al.
Publicado: (2013)

Two Receptors, Two Isoforms, Two Cancers: Comprehensive Analysis of KIT and TrkA Expression in Neuroblastoma and Acute Myeloid Leukemia
por: Lebedev, Timofey D., et al.
Publicado: (2019)

NTRK1/TrkA Signaling in Neuroblastoma Cells Induces Nuclear Reorganization and Intra-Nuclear Aggregation of Lamin A/C
por: Funke, Lukas, et al.
Publicado: (2021)

MYCN-enhanced Oxidative and Glycolytic Metabolism Reveals Vulnerabilities for Targeting Neuroblastoma
por: Oliynyk, Ganna, et al.
Publicado: (2019)

Neuroblastoma patient-derived xenograft cells cultured in stem-cell promoting medium retain tumorigenic and metastatic capacities but differentiate in serum
por: Persson, Camilla U., et al.
Publicado: (2017)

Proteomic analysis of novel targets associated with TrkA-mediated tyrosine phosphorylation signaling pathways in SK-N-MC neuroblastoma cells
por: Wu, Fang-Xiang, et al.
Publicado: (2013)

C1GALT1 expression predicts a favorable prognosis and suppresses malignant phenotypes via TrkA signaling in neuroblastoma
por: Lin, Neng-Yu, et al.
Publicado: (2022)

CD25(bright) NK cells display superior function and metabolic activity under regulatory T cell-mediated suppression
por: Chen, Ziqing, et al.
Publicado: (2023)

Autocrine Prostaglandin E(2) Signaling Promotes Tumor Cell Survival and Proliferation in Childhood Neuroblastoma
por: Rasmuson, Agnes, et al.
Publicado: (2012)

Target Genes of c-MYC and MYCN with Prognostic Power in Neuroblastoma Exhibit Different Expressions during Sympathoadrenal Development
por: Yuan, Ye, et al.
Publicado: (2023)

Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci
por: Sen, Sonia Q, et al.
Publicado: (2019)

Seven-up acts in neuroblasts to specify adult central complex neuron identity and initiate neuroblast decommissioning
por: Dillon, Noah R., et al.
Publicado: (2023)

Neuroblastoma-related inflammation: May small doses of aspirin be suitable for small cancer patients?
por: Carlson, Lena-Maria, et al.
Publicado: (2013)

TrkA is a binding partner of NPM‐ALK that promotes the survival of ALK (+) T‐cell lymphoma
por: Shi, Wenyu, et al.
Publicado: (2017)

NGF – the TrkA to successful pain treatment
por: Kumar, Vinayak, et al.
Publicado: (2012)

Characterization of TRKA signaling in acute myeloid leukemia
por: Herbrich, Shelley M., et al.
Publicado: (2018)

Sumoylation of Notch1 represses its target gene expression during cell stress
por: Antila, Christian J. M., et al.
Publicado: (2018)

Limited neuropeptide Y precursor processing in unfavourable metastatic neuroblastoma tumours
por: Bjellerup, P, et al.
Publicado: (2000)

Cannot write session to /tmp/vufind_sessions/sess_iaau75e3qvllu2d9jpbiuirr3j