p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity

DNA methylation is a key regulator of embryonic stem cell (ESC) biology, dynamically changing between naïve, primed, and differentiated states. The p53 tumor suppressor is a pivotal guardian of genomic stability, but its contributions to epigenetic regulation and stem cell biology are less explored....

Descripción completa

Detalles Bibliográficos
Autores principales: Tovy, Ayala, Spiro, Adam, McCarthy, Ryan, Shipony, Zohar, Aylon, Yael, Allton, Kendra, Ainbinder, Elena, Furth, Noa, Tanay, Amos, Barton, Michelle, Oren, Moshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495125/
https://www.ncbi.nlm.nih.gov/pubmed/28607180
http://dx.doi.org/10.1101/gad.299198.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495125/
https://www.ncbi.nlm.nih.gov/pubmed/28607180
http://dx.doi.org/10.1101/gad.299198.117

Ejemplares similares