Depletion of runt-related transcription factor 2 (RUNX2) enhances SAHA sensitivity of p53-mutated pancreatic cancer cells through the regulation of mutant p53 and TAp63

Suberoylanilide hydroxamic acid (SAHA) represents one of the new class of anti-cancer drugs. However, multiple lines of clinical evidence indicate that SAHA might be sometimes ineffective on certain solid tumors including pancreatic cancer. In this study, we have found for the first time that RUNX2/...

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Detalles Bibliográficos
Autores principales: Ogata, Takehiro, Nakamura, Mizuyo, Sang, Meijie, Yoda, Hiroyuki, Hiraoka, Kiriko, Yin, Danjing, Sang, Mexiang, Shimozato, Osamu, Ozaki, Toshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495219/
https://www.ncbi.nlm.nih.gov/pubmed/28671946
http://dx.doi.org/10.1371/journal.pone.0179884

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