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Splicing stimulates siRNA formation at Drosophila DNA double-strand breaks

DNA double-strand breaks trigger the production of locus-derived siRNAs in fruit flies, human cells and plants. At least in flies, their biogenesis depends on active transcription running towards the break. Since siRNAs derive from a double-stranded RNA precursor, a major question is how broken DNA...

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Detalles Bibliográficos
Autores principales:	Merk, Karin, Breinig, Marco, Böttcher, Romy, Krebs, Stefan, Blum, Helmut, Boutros, Michael, Förstemann, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495518/ https://www.ncbi.nlm.nih.gov/pubmed/28628606 http://dx.doi.org/10.1371/journal.pgen.1006861

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