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Amount of fear extinction changes its underlying mechanisms

There has been a longstanding debate on whether original fear memory is inhibited or erased after extinction. One possibility that reconciles this uncertainty is that the inhibition and erasure mechanisms are engaged in different phases (early or late) of extinction. In this study, using single-sess...

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Autores principales: An, Bobae, Kim, Jihye, Park, Kyungjoon, Lee, Sukwon, Song, Sukwoon, Choi, Sukwoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495569/
https://www.ncbi.nlm.nih.gov/pubmed/28671550
http://dx.doi.org/10.7554/eLife.25224
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author An, Bobae
Kim, Jihye
Park, Kyungjoon
Lee, Sukwon
Song, Sukwoon
Choi, Sukwoo
author_facet An, Bobae
Kim, Jihye
Park, Kyungjoon
Lee, Sukwon
Song, Sukwoon
Choi, Sukwoo
author_sort An, Bobae
collection PubMed
description There has been a longstanding debate on whether original fear memory is inhibited or erased after extinction. One possibility that reconciles this uncertainty is that the inhibition and erasure mechanisms are engaged in different phases (early or late) of extinction. In this study, using single-session extinction training and its repetition (multiple-session extinction training), we investigated the inhibition and erasure mechanisms in the prefrontal cortex and amygdala of rats, where neural circuits underlying extinction reside. The inhibition mechanism was prevalent with single-session extinction training but faded when single-session extinction training was repeated. In contrast, the erasure mechanism became prevalent when single-session extinction training was repeated. Moreover, ablating the intercalated neurons of amygdala, which are responsible for maintaining extinction-induced inhibition, was no longer effective in multiple-session extinction training. We propose that the inhibition mechanism operates primarily in the early phase of extinction training, and the erasure mechanism takes over after that. DOI: http://dx.doi.org/10.7554/eLife.25224.001
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spelling pubmed-54955692017-07-05 Amount of fear extinction changes its underlying mechanisms An, Bobae Kim, Jihye Park, Kyungjoon Lee, Sukwon Song, Sukwoon Choi, Sukwoo eLife Neuroscience There has been a longstanding debate on whether original fear memory is inhibited or erased after extinction. One possibility that reconciles this uncertainty is that the inhibition and erasure mechanisms are engaged in different phases (early or late) of extinction. In this study, using single-session extinction training and its repetition (multiple-session extinction training), we investigated the inhibition and erasure mechanisms in the prefrontal cortex and amygdala of rats, where neural circuits underlying extinction reside. The inhibition mechanism was prevalent with single-session extinction training but faded when single-session extinction training was repeated. In contrast, the erasure mechanism became prevalent when single-session extinction training was repeated. Moreover, ablating the intercalated neurons of amygdala, which are responsible for maintaining extinction-induced inhibition, was no longer effective in multiple-session extinction training. We propose that the inhibition mechanism operates primarily in the early phase of extinction training, and the erasure mechanism takes over after that. DOI: http://dx.doi.org/10.7554/eLife.25224.001 eLife Sciences Publications, Ltd 2017-07-03 /pmc/articles/PMC5495569/ /pubmed/28671550 http://dx.doi.org/10.7554/eLife.25224 Text en © 2017, An et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
An, Bobae
Kim, Jihye
Park, Kyungjoon
Lee, Sukwon
Song, Sukwoon
Choi, Sukwoo
Amount of fear extinction changes its underlying mechanisms
title Amount of fear extinction changes its underlying mechanisms
title_full Amount of fear extinction changes its underlying mechanisms
title_fullStr Amount of fear extinction changes its underlying mechanisms
title_full_unstemmed Amount of fear extinction changes its underlying mechanisms
title_short Amount of fear extinction changes its underlying mechanisms
title_sort amount of fear extinction changes its underlying mechanisms
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495569/
https://www.ncbi.nlm.nih.gov/pubmed/28671550
http://dx.doi.org/10.7554/eLife.25224
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