Optimized T-cell receptor-mimic chimeric antigen receptor T cells directed toward the intracellular Wilms Tumor 1 antigen

CD19-directed chimeric antigen receptor (CAR) T cells are clinically effective in a limited set of leukemia patients. However, CAR T-cell therapy thus far has been largely restricted to targeting extracellular tumor-associated antigens (TAA). Herein, we report a T-cell receptor-mimic (TCRm) CAR, ter...

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Detalles Bibliográficos
Autores principales: Rafiq, S, Purdon, TJ, Daniyan, AF, Koneru, M, Dao, T, Liu, C, Scheinberg, DA, Brentjens, RJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495623/
https://www.ncbi.nlm.nih.gov/pubmed/27924074
http://dx.doi.org/10.1038/leu.2016.373

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