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Optimized T-cell receptor-mimic chimeric antigen receptor T cells directed toward the intracellular Wilms Tumor 1 antigen
CD19-directed chimeric antigen receptor (CAR) T cells are clinically effective in a limited set of leukemia patients. However, CAR T-cell therapy thus far has been largely restricted to targeting extracellular tumor-associated antigens (TAA). Herein, we report a T-cell receptor-mimic (TCRm) CAR, ter...
Autores principales: | Rafiq, S, Purdon, TJ, Daniyan, AF, Koneru, M, Dao, T, Liu, C, Scheinberg, DA, Brentjens, RJ |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495623/ https://www.ncbi.nlm.nih.gov/pubmed/27924074 http://dx.doi.org/10.1038/leu.2016.373 |
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