Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors

Botulinum neurotoxin B is a Food and Drug Administration-approved therapeutic toxin. However, it has lower binding affinity toward the human version of its major receptor, synaptotagmin II (h-Syt II), compared to mouse Syt II, because of a residue difference. Increasing the binding affinity to h-Syt...

Descripción completa

Detalles Bibliográficos
Autores principales: Tao, Liang, Peng, Lisheng, Berntsson, Ronnie P.-A., Liu, Sai Man, Park, SunHyun, Yu, Feifan, Boone, Christopher, Palan, Shilpa, Beard, Matthew, Chabrier, Pierre-Etienne, Stenmark, Pål, Krupp, Johannes, Dong, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495808/
https://www.ncbi.nlm.nih.gov/pubmed/28674381
http://dx.doi.org/10.1038/s41467-017-00064-y

Ejemplares similares

Ejemplares similares