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Trastuzumab uptake and its relation to efficacy in an animal model of HER2-positive breast cancer brain metastasis

PURPOSE: The extent to which efficacy of the HER2 antibody Trastuzumab in brain metastases is limited by access of antibody to brain lesions remains a question of significant clinical importance. We investigated the uptake and distribution of trastuzumab in brain and mammary fat pad grafts of HER2-p...

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Detalles Bibliográficos
Autores principales:	Lewis Phillips, Gail D., Nishimura, Merry C., Lacap, Jennifer Arca, Kharbanda, Samir, Mai, Elaine, Tien, Janet, Malesky, Kimberly, Williams, Simon P., Marik, Jan, Phillips, Heidi S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2017
Materias:	Preclinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495871/ https://www.ncbi.nlm.nih.gov/pubmed/28493046 http://dx.doi.org/10.1007/s10549-017-4279-4

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