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Measuring levels of osteopontin as potential biomarker for hepatocellular carcinoma in Syrian patients
AIM: This study aims to evaluate plasma osteopontin (OPN) levels as a potential biomarker for hepatocellular carcinoma (HCC). BACKGROUND: Osteopontin (OPN) is a secreted glycoprotein that is associated with tumorigenesis and metastasis. METHODS: We measured plasma levels of OPN in 26 HCC patients, 2...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495895/ https://www.ncbi.nlm.nih.gov/pubmed/28702132 |
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author | Al-Zoubi, Sara Wassouf, Ahmad Zetoune, Almoutassem Billah |
author_facet | Al-Zoubi, Sara Wassouf, Ahmad Zetoune, Almoutassem Billah |
author_sort | Al-Zoubi, Sara |
collection | PubMed |
description | AIM: This study aims to evaluate plasma osteopontin (OPN) levels as a potential biomarker for hepatocellular carcinoma (HCC). BACKGROUND: Osteopontin (OPN) is a secreted glycoprotein that is associated with tumorigenesis and metastasis. METHODS: We measured plasma levels of OPN in 26 HCC patients, 27 patients with chronic liver diseases (CLD), and 15 healthy control individuals using a standardized ELISA kit. RESULTS: The mean plasma OPN level was significantly higher in the HCC group than the CLD group or the normal control group (p-value =0.001/<0.0001). Plasma OPN levels were significantly higher in patients with a tumor size >5 cm in diameter than those with tumors ≤5 cm (p=0.02). OPN levels in the HCC group were not significantly affected by advancing degree of Child-Pugh class. Diagnostic sensitivity and specificity of OPN for HCC were 61% and 82%, respectively (cut-off value: 118.69ng/mL). The area under the ROC curve (AUC) value for OPN was 0.784. However, the AUC value was 0.844 for AFP. CONCLUSION: The plasma levels of OPN show low diagnostic accuracy for HCC compared to AFP. However, OPN may have a complementary role in diagnosing HCC in patients with non-diagnostic levels of AFP. |
format | Online Article Text |
id | pubmed-5495895 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-54958952017-07-12 Measuring levels of osteopontin as potential biomarker for hepatocellular carcinoma in Syrian patients Al-Zoubi, Sara Wassouf, Ahmad Zetoune, Almoutassem Billah Gastroenterol Hepatol Bed Bench Original Article AIM: This study aims to evaluate plasma osteopontin (OPN) levels as a potential biomarker for hepatocellular carcinoma (HCC). BACKGROUND: Osteopontin (OPN) is a secreted glycoprotein that is associated with tumorigenesis and metastasis. METHODS: We measured plasma levels of OPN in 26 HCC patients, 27 patients with chronic liver diseases (CLD), and 15 healthy control individuals using a standardized ELISA kit. RESULTS: The mean plasma OPN level was significantly higher in the HCC group than the CLD group or the normal control group (p-value =0.001/<0.0001). Plasma OPN levels were significantly higher in patients with a tumor size >5 cm in diameter than those with tumors ≤5 cm (p=0.02). OPN levels in the HCC group were not significantly affected by advancing degree of Child-Pugh class. Diagnostic sensitivity and specificity of OPN for HCC were 61% and 82%, respectively (cut-off value: 118.69ng/mL). The area under the ROC curve (AUC) value for OPN was 0.784. However, the AUC value was 0.844 for AFP. CONCLUSION: The plasma levels of OPN show low diagnostic accuracy for HCC compared to AFP. However, OPN may have a complementary role in diagnosing HCC in patients with non-diagnostic levels of AFP. Shaheed Beheshti University of Medical Sciences 2017 /pmc/articles/PMC5495895/ /pubmed/28702132 Text en ©2017 RIGLD, Research Institute for Gastroenterology and Liver Diseases This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Al-Zoubi, Sara Wassouf, Ahmad Zetoune, Almoutassem Billah Measuring levels of osteopontin as potential biomarker for hepatocellular carcinoma in Syrian patients |
title | Measuring levels of osteopontin as potential biomarker for hepatocellular carcinoma in Syrian patients |
title_full | Measuring levels of osteopontin as potential biomarker for hepatocellular carcinoma in Syrian patients |
title_fullStr | Measuring levels of osteopontin as potential biomarker for hepatocellular carcinoma in Syrian patients |
title_full_unstemmed | Measuring levels of osteopontin as potential biomarker for hepatocellular carcinoma in Syrian patients |
title_short | Measuring levels of osteopontin as potential biomarker for hepatocellular carcinoma in Syrian patients |
title_sort | measuring levels of osteopontin as potential biomarker for hepatocellular carcinoma in syrian patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495895/ https://www.ncbi.nlm.nih.gov/pubmed/28702132 |
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