Hyperbaric oxygen treatment of spinal cord injury in rat model

BACKGROUND: The purpose of this study was to investigate the therapeutic effects and mechanisms of hyperbaric oxygen (HBO) treatment on rats following spinal cord injury (SCI). METHODS: A total of 45 Sprague-Dawley (SD) rats were randomly divided into three groups. Sham-SCI group was surgically expo...

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Autores principales: Sun, Yongming, Liu, Dong, Wang, Qingpeng, Su, Peng, Tang, Qifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496131/
https://www.ncbi.nlm.nih.gov/pubmed/28673282
http://dx.doi.org/10.1186/s12883-017-0909-z
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author Sun, Yongming
Liu, Dong
Wang, Qingpeng
Su, Peng
Tang, Qifeng
author_facet Sun, Yongming
Liu, Dong
Wang, Qingpeng
Su, Peng
Tang, Qifeng
author_sort Sun, Yongming
collection PubMed
description BACKGROUND: The purpose of this study was to investigate the therapeutic effects and mechanisms of hyperbaric oxygen (HBO) treatment on rats following spinal cord injury (SCI). METHODS: A total of 45 Sprague-Dawley (SD) rats were randomly divided into three groups. Sham-SCI group was surgically exposed but not subjected to the SCI procedure. SCI-control group was administered SCI and treated with regular air. SCI-HBO group was administered SCI and HBO treatment. Neuromotor functions were examined using the Basso, Beattie, and Bresnahan (BBB) locomotor rating scale and the inclined plane assessment at before SCI (baseline) and after SCI. Superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels were measured. RESULTS: Starting from Day 1 after SCI but except Day 2, the SCI-HBO group has significantly higher BBB scores than the SCI-control group. After SCI, the maximum inclination angles at which rats could maintain were significantly lower in both SCI groups. But the maximum angles were significantly bigger for the rats in the SCI-HBO group than those on the SCI-control group at 5, 10 and 20 days after SCI. SOD activities in SCI-HBO rats were significantly higher and MDA levels were significantly lower than in SCI-control rats, at two and five days after SCI. There was also less cystic degeneration of spinal cord in SCI-HBO rats, compared to SCI-control rats. CONCLUSIONS: These results suggest that HBO treatment has a therapeutic value in treating SCI. Increased oxygen free radical scavenging and reduced lipid oxidation may be one of the mechanisms.
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spelling pubmed-54961312017-07-05 Hyperbaric oxygen treatment of spinal cord injury in rat model Sun, Yongming Liu, Dong Wang, Qingpeng Su, Peng Tang, Qifeng BMC Neurol Research Article BACKGROUND: The purpose of this study was to investigate the therapeutic effects and mechanisms of hyperbaric oxygen (HBO) treatment on rats following spinal cord injury (SCI). METHODS: A total of 45 Sprague-Dawley (SD) rats were randomly divided into three groups. Sham-SCI group was surgically exposed but not subjected to the SCI procedure. SCI-control group was administered SCI and treated with regular air. SCI-HBO group was administered SCI and HBO treatment. Neuromotor functions were examined using the Basso, Beattie, and Bresnahan (BBB) locomotor rating scale and the inclined plane assessment at before SCI (baseline) and after SCI. Superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels were measured. RESULTS: Starting from Day 1 after SCI but except Day 2, the SCI-HBO group has significantly higher BBB scores than the SCI-control group. After SCI, the maximum inclination angles at which rats could maintain were significantly lower in both SCI groups. But the maximum angles were significantly bigger for the rats in the SCI-HBO group than those on the SCI-control group at 5, 10 and 20 days after SCI. SOD activities in SCI-HBO rats were significantly higher and MDA levels were significantly lower than in SCI-control rats, at two and five days after SCI. There was also less cystic degeneration of spinal cord in SCI-HBO rats, compared to SCI-control rats. CONCLUSIONS: These results suggest that HBO treatment has a therapeutic value in treating SCI. Increased oxygen free radical scavenging and reduced lipid oxidation may be one of the mechanisms. BioMed Central 2017-07-03 /pmc/articles/PMC5496131/ /pubmed/28673282 http://dx.doi.org/10.1186/s12883-017-0909-z Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Sun, Yongming
Liu, Dong
Wang, Qingpeng
Su, Peng
Tang, Qifeng
Hyperbaric oxygen treatment of spinal cord injury in rat model
title Hyperbaric oxygen treatment of spinal cord injury in rat model
title_full Hyperbaric oxygen treatment of spinal cord injury in rat model
title_fullStr Hyperbaric oxygen treatment of spinal cord injury in rat model
title_full_unstemmed Hyperbaric oxygen treatment of spinal cord injury in rat model
title_short Hyperbaric oxygen treatment of spinal cord injury in rat model
title_sort hyperbaric oxygen treatment of spinal cord injury in rat model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496131/
https://www.ncbi.nlm.nih.gov/pubmed/28673282
http://dx.doi.org/10.1186/s12883-017-0909-z
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