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Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy

BACKGROUND: Alpha-synuclein (α-syn) aggregation represents the pathological hallmark of α-synucleinopathies like Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Toll-like receptors (TLRs) are a family of highly conserved molecules that recognize pathogen...

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Detalles Bibliográficos
Autores principales:	Venezia, Serena, Refolo, Violetta, Polissidis, Alexia, Stefanis, Leonidas, Wenning, Gregor K., Stefanova, Nadia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496237/ https://www.ncbi.nlm.nih.gov/pubmed/28676095 http://dx.doi.org/10.1186/s13024-017-0195-7

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