Cargando…

Acquired aplastic anemia associated with trisomy eight converting into acute myeloid leukemia

Aplastic anemia (AA) is nowadays considered to be a clonal disorder arising from a defective hematopoietic stem cell developing after a generalized insult to bone marrow. Immunosuppressive treatment (IST) of AA causes suppression of the target dominant population of haematopoietic cells allowing the...

Descripción completa

Detalles Bibliográficos
Autores principales: Grover, Sumit, Dhiman, Amit Kumar, Garg, Bhavna, Sood, Neena, Narang, Vikram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496300/
https://www.ncbi.nlm.nih.gov/pubmed/28706392
http://dx.doi.org/10.4103/0974-2727.208259
_version_ 1783247948445908992
author Grover, Sumit
Dhiman, Amit Kumar
Garg, Bhavna
Sood, Neena
Narang, Vikram
author_facet Grover, Sumit
Dhiman, Amit Kumar
Garg, Bhavna
Sood, Neena
Narang, Vikram
author_sort Grover, Sumit
collection PubMed
description Aplastic anemia (AA) is nowadays considered to be a clonal disorder arising from a defective hematopoietic stem cell developing after a generalized insult to bone marrow. Immunosuppressive treatment (IST) of AA causes suppression of the target dominant population of haematopoietic cells allowing the defective non targeted clones to expand. This may give rise to acute leukemia. Cytogenetic studies for chromosomal aberrations such as trisomy and monosomy may help in detecting such conversions. We present a case of acquired AA in a 60-year-old male presenting with pancytopenia and hypoplastic marrow treated with antithymocyte globulin, converting into myelodysplastic syndrome and later on acute promyelocytic leukemia after being in remission for 4 years. The patient was found to have trisomy 8 on fluorescence in situ hybridization and karyotyping.
format Online
Article
Text
id pubmed-5496300
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-54963002017-07-13 Acquired aplastic anemia associated with trisomy eight converting into acute myeloid leukemia Grover, Sumit Dhiman, Amit Kumar Garg, Bhavna Sood, Neena Narang, Vikram J Lab Physicians Case Report Aplastic anemia (AA) is nowadays considered to be a clonal disorder arising from a defective hematopoietic stem cell developing after a generalized insult to bone marrow. Immunosuppressive treatment (IST) of AA causes suppression of the target dominant population of haematopoietic cells allowing the defective non targeted clones to expand. This may give rise to acute leukemia. Cytogenetic studies for chromosomal aberrations such as trisomy and monosomy may help in detecting such conversions. We present a case of acquired AA in a 60-year-old male presenting with pancytopenia and hypoplastic marrow treated with antithymocyte globulin, converting into myelodysplastic syndrome and later on acute promyelocytic leukemia after being in remission for 4 years. The patient was found to have trisomy 8 on fluorescence in situ hybridization and karyotyping. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5496300/ /pubmed/28706392 http://dx.doi.org/10.4103/0974-2727.208259 Text en Copyright: © 2017 Journal of Laboratory Physicians http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Grover, Sumit
Dhiman, Amit Kumar
Garg, Bhavna
Sood, Neena
Narang, Vikram
Acquired aplastic anemia associated with trisomy eight converting into acute myeloid leukemia
title Acquired aplastic anemia associated with trisomy eight converting into acute myeloid leukemia
title_full Acquired aplastic anemia associated with trisomy eight converting into acute myeloid leukemia
title_fullStr Acquired aplastic anemia associated with trisomy eight converting into acute myeloid leukemia
title_full_unstemmed Acquired aplastic anemia associated with trisomy eight converting into acute myeloid leukemia
title_short Acquired aplastic anemia associated with trisomy eight converting into acute myeloid leukemia
title_sort acquired aplastic anemia associated with trisomy eight converting into acute myeloid leukemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496300/
https://www.ncbi.nlm.nih.gov/pubmed/28706392
http://dx.doi.org/10.4103/0974-2727.208259
work_keys_str_mv AT groversumit acquiredaplasticanemiaassociatedwithtrisomyeightconvertingintoacutemyeloidleukemia
AT dhimanamitkumar acquiredaplasticanemiaassociatedwithtrisomyeightconvertingintoacutemyeloidleukemia
AT gargbhavna acquiredaplasticanemiaassociatedwithtrisomyeightconvertingintoacutemyeloidleukemia
AT soodneena acquiredaplasticanemiaassociatedwithtrisomyeightconvertingintoacutemyeloidleukemia
AT narangvikram acquiredaplasticanemiaassociatedwithtrisomyeightconvertingintoacutemyeloidleukemia