BRCA1 reversion mutation acquired after treatment identified by liquid biopsy

• Secondary, reversion mutations in BRCA genes can restore protein function. • Reversion mutations can underlie resistance to therapies such as PARP inhibitors. • Reversion mutations arise during the course of treatment.

Detalles Bibliográficos
Autores principales: Mayor, Paul, Gay, Laurie M., Lele, Shashikant, Elvin, Julia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496455/
https://www.ncbi.nlm.nih.gov/pubmed/28706968
http://dx.doi.org/10.1016/j.gore.2017.06.010

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