Cargando…

Longitudinal MR spectroscopy of neurodegeneration in multiple sclerosis with diffusion of the intra-axonal constituent N-acetylaspartate

Multiple sclerosis (MS) is a pathologically complex CNS disease: inflammation, demyelination, and neuroaxonal degeneration occur concurrently and may depend on one another. Current therapies are aimed at the immune-mediated, inflammatory destruction of myelin, whereas axonal degeneration is ongoing...

Descripción completa

Detalles Bibliográficos
Autores principales: Wood, Emily Turner, Ercan, Ece, Sati, Pascal, Cortese, Irene C.M., Ronen, Itamar, Reich, Daniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496488/
https://www.ncbi.nlm.nih.gov/pubmed/28702353
http://dx.doi.org/10.1016/j.nicl.2017.06.028
_version_ 1783247989801746432
author Wood, Emily Turner
Ercan, Ece
Sati, Pascal
Cortese, Irene C.M.
Ronen, Itamar
Reich, Daniel S.
author_facet Wood, Emily Turner
Ercan, Ece
Sati, Pascal
Cortese, Irene C.M.
Ronen, Itamar
Reich, Daniel S.
author_sort Wood, Emily Turner
collection PubMed
description Multiple sclerosis (MS) is a pathologically complex CNS disease: inflammation, demyelination, and neuroaxonal degeneration occur concurrently and may depend on one another. Current therapies are aimed at the immune-mediated, inflammatory destruction of myelin, whereas axonal degeneration is ongoing and not specifically targeted. Diffusion-weighted magnetic resonance spectroscopy can measure the diffusivity of metabolites in vivo, such as the axonal/neuronal constituent N-acetylaspartate, allowing compartment-specific assessment of disease-related changes. Previously, we found significantly lower N-acetylaspartate diffusivity in people with MS compared to healthy controls (Wood et al., 2012) suggesting that this technique can measure axonal degeneration and could be useful in developing neuroprotective agents. In this longitudinal study, we found that N-acetylaspartate diffusivity decreased by 8.3% (p < 0.05) over 6 months in participants who were experiencing clinical or MRI evidence of inflammatory activity (n = 13), whereas there was no significant change in N-acetylaspartate diffusivity in the context of clinical and radiological stability (n = 6). As N-acetylaspartate diffusivity measurements are thought to more specifically reflect the intra-axonal space, these data suggest that N-acetylaspartate diffusivity can report on axonal health on the background of multiple pathological processes in MS, both cross-sectionally and longitudinally.
format Online
Article
Text
id pubmed-5496488
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-54964882017-07-12 Longitudinal MR spectroscopy of neurodegeneration in multiple sclerosis with diffusion of the intra-axonal constituent N-acetylaspartate Wood, Emily Turner Ercan, Ece Sati, Pascal Cortese, Irene C.M. Ronen, Itamar Reich, Daniel S. Neuroimage Clin Regular Article Multiple sclerosis (MS) is a pathologically complex CNS disease: inflammation, demyelination, and neuroaxonal degeneration occur concurrently and may depend on one another. Current therapies are aimed at the immune-mediated, inflammatory destruction of myelin, whereas axonal degeneration is ongoing and not specifically targeted. Diffusion-weighted magnetic resonance spectroscopy can measure the diffusivity of metabolites in vivo, such as the axonal/neuronal constituent N-acetylaspartate, allowing compartment-specific assessment of disease-related changes. Previously, we found significantly lower N-acetylaspartate diffusivity in people with MS compared to healthy controls (Wood et al., 2012) suggesting that this technique can measure axonal degeneration and could be useful in developing neuroprotective agents. In this longitudinal study, we found that N-acetylaspartate diffusivity decreased by 8.3% (p < 0.05) over 6 months in participants who were experiencing clinical or MRI evidence of inflammatory activity (n = 13), whereas there was no significant change in N-acetylaspartate diffusivity in the context of clinical and radiological stability (n = 6). As N-acetylaspartate diffusivity measurements are thought to more specifically reflect the intra-axonal space, these data suggest that N-acetylaspartate diffusivity can report on axonal health on the background of multiple pathological processes in MS, both cross-sectionally and longitudinally. Elsevier 2017-06-22 /pmc/articles/PMC5496488/ /pubmed/28702353 http://dx.doi.org/10.1016/j.nicl.2017.06.028 Text en http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Article
Wood, Emily Turner
Ercan, Ece
Sati, Pascal
Cortese, Irene C.M.
Ronen, Itamar
Reich, Daniel S.
Longitudinal MR spectroscopy of neurodegeneration in multiple sclerosis with diffusion of the intra-axonal constituent N-acetylaspartate
title Longitudinal MR spectroscopy of neurodegeneration in multiple sclerosis with diffusion of the intra-axonal constituent N-acetylaspartate
title_full Longitudinal MR spectroscopy of neurodegeneration in multiple sclerosis with diffusion of the intra-axonal constituent N-acetylaspartate
title_fullStr Longitudinal MR spectroscopy of neurodegeneration in multiple sclerosis with diffusion of the intra-axonal constituent N-acetylaspartate
title_full_unstemmed Longitudinal MR spectroscopy of neurodegeneration in multiple sclerosis with diffusion of the intra-axonal constituent N-acetylaspartate
title_short Longitudinal MR spectroscopy of neurodegeneration in multiple sclerosis with diffusion of the intra-axonal constituent N-acetylaspartate
title_sort longitudinal mr spectroscopy of neurodegeneration in multiple sclerosis with diffusion of the intra-axonal constituent n-acetylaspartate
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496488/
https://www.ncbi.nlm.nih.gov/pubmed/28702353
http://dx.doi.org/10.1016/j.nicl.2017.06.028
work_keys_str_mv AT woodemilyturner longitudinalmrspectroscopyofneurodegenerationinmultiplesclerosiswithdiffusionoftheintraaxonalconstituentnacetylaspartate
AT ercanece longitudinalmrspectroscopyofneurodegenerationinmultiplesclerosiswithdiffusionoftheintraaxonalconstituentnacetylaspartate
AT satipascal longitudinalmrspectroscopyofneurodegenerationinmultiplesclerosiswithdiffusionoftheintraaxonalconstituentnacetylaspartate
AT corteseirenecm longitudinalmrspectroscopyofneurodegenerationinmultiplesclerosiswithdiffusionoftheintraaxonalconstituentnacetylaspartate
AT ronenitamar longitudinalmrspectroscopyofneurodegenerationinmultiplesclerosiswithdiffusionoftheintraaxonalconstituentnacetylaspartate
AT reichdaniels longitudinalmrspectroscopyofneurodegenerationinmultiplesclerosiswithdiffusionoftheintraaxonalconstituentnacetylaspartate