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The EMT spectrum and therapeutic opportunities
Carcinomas are phenotypically arrayed along an epithelial–mesenchymal transition (EMT) spectrum, a developmental program currently exploited to understand the acquisition of drug resistance through a re‐routing of growth factor signaling. This review collates the current approaches employed in devel...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496500/ https://www.ncbi.nlm.nih.gov/pubmed/28544151 http://dx.doi.org/10.1002/1878-0261.12082 |
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author | Voon, Dominic C. Huang, Ruby Y. Jackson, Rebecca A. Thiery, Jean P. |
author_facet | Voon, Dominic C. Huang, Ruby Y. Jackson, Rebecca A. Thiery, Jean P. |
author_sort | Voon, Dominic C. |
collection | PubMed |
description | Carcinomas are phenotypically arrayed along an epithelial–mesenchymal transition (EMT) spectrum, a developmental program currently exploited to understand the acquisition of drug resistance through a re‐routing of growth factor signaling. This review collates the current approaches employed in developing therapeutics against cancer‐associated EMT, and provides an assessment of their respective strengths and drawbacks. We reflect on the close relationship between EMT and chemoresistance against current targeted therapeutics, with a special focus on the epigenetic mechanisms that link these processes. This prompts the hypothesis that carcinoma‐associated EMT shares a common epigenetic pathway to cellular plasticity as somatic cell reprogramming during tissue repair and regeneration. Indeed, their striking resemblance suggests that EMT in carcinoma is a pathological adaptation of an intrinsic program of cellular plasticity that is crucial to tissue homeostasis. We thus propose a revised approach that targets the epigenetic mechanisms underlying pathogenic EMT to arrest cellular plasticity regardless of upstream cancer‐driving mutations. |
format | Online Article Text |
id | pubmed-5496500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54965002017-07-18 The EMT spectrum and therapeutic opportunities Voon, Dominic C. Huang, Ruby Y. Jackson, Rebecca A. Thiery, Jean P. Mol Oncol Reviews Carcinomas are phenotypically arrayed along an epithelial–mesenchymal transition (EMT) spectrum, a developmental program currently exploited to understand the acquisition of drug resistance through a re‐routing of growth factor signaling. This review collates the current approaches employed in developing therapeutics against cancer‐associated EMT, and provides an assessment of their respective strengths and drawbacks. We reflect on the close relationship between EMT and chemoresistance against current targeted therapeutics, with a special focus on the epigenetic mechanisms that link these processes. This prompts the hypothesis that carcinoma‐associated EMT shares a common epigenetic pathway to cellular plasticity as somatic cell reprogramming during tissue repair and regeneration. Indeed, their striking resemblance suggests that EMT in carcinoma is a pathological adaptation of an intrinsic program of cellular plasticity that is crucial to tissue homeostasis. We thus propose a revised approach that targets the epigenetic mechanisms underlying pathogenic EMT to arrest cellular plasticity regardless of upstream cancer‐driving mutations. John Wiley and Sons Inc. 2017-06-19 2017-07 /pmc/articles/PMC5496500/ /pubmed/28544151 http://dx.doi.org/10.1002/1878-0261.12082 Text en © 2017 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Voon, Dominic C. Huang, Ruby Y. Jackson, Rebecca A. Thiery, Jean P. The EMT spectrum and therapeutic opportunities |
title | The EMT spectrum and therapeutic opportunities |
title_full | The EMT spectrum and therapeutic opportunities |
title_fullStr | The EMT spectrum and therapeutic opportunities |
title_full_unstemmed | The EMT spectrum and therapeutic opportunities |
title_short | The EMT spectrum and therapeutic opportunities |
title_sort | emt spectrum and therapeutic opportunities |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496500/ https://www.ncbi.nlm.nih.gov/pubmed/28544151 http://dx.doi.org/10.1002/1878-0261.12082 |
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