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Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonist
The development of MET receptor agonists is an important goal in regenerative medicine, but is limited by the complexity and incomplete understanding of its interaction with HGF/SF (Hepatocyte Growth Factor/Scatter Factor). NK1 is a natural occurring agonist comprising the N-terminal (N) and the fir...
Autores principales: | Simonneau, Claire, Bérénice Leclercq, Mougel, Alexandra, Adriaenssens, Eric, Paquet, Charlotte, Raibaut, Laurent, Ollivier, Nathalie, Drobecq, Hervé, Marcoux, Julien, Cianférani, Sarah, Tulasne, David, de Jonge, Hugo, Melnyk, Oleg, Vicogne, Jérôme |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496502/ https://www.ncbi.nlm.nih.gov/pubmed/28717459 http://dx.doi.org/10.1039/c4sc03856h |
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